550-33-4

• 常用中文名：9-(Β-D -呋喃核糖)嘌呤
• 常用英文名：NEBULARINE
• CAS号：550-33-4
• 分子式：C₁₀H₁₂N₄O₄
• 分子量：252.23
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2018-12-27 18:13:58
• 更新时间：2024-01-04 09:40:03
• 尼布拉里是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: 9-(Β-D -呋喃核糖)嘌呤
• 英文名: nebularine
• 英文别名: PURINE RIBOSIDE; ribosyl-purin; Purinosine; Ribosyl-isopurine; NEBULARINE; 6-deaMinoadenosine; 9-purineribonucleoside; PURINE RIBONUCLEOSIDE; ribosylpurine

物化性质

• 密度: 1.91g/cm3
• 沸点: 591.6ºC at 760mmHg
• 熔点: 181-182ºC
• 分子式: C₁₀H₁₂N₄O₄
• 分子量: 252.23
• 闪点: 311.6ºC
• 精确质量: 252.08600
• PSA: 113.52000
• 折射率: 1.837

生物活性

• 描述: 尼布拉里是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UO9100000 CHEMICAL NAME : 9H-Purine, 9-beta-D-ribofuranosyl- CAS REGISTRY NUMBER : 550-33-4 BEILSTEIN REFERENCE NO. : 0091539 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C10-H12-N4-O4 MOLECULAR WEIGHT : 252.26 WISWESSER LINE NOTATION : T56 BN DN FN HNJ B- BT5OTJ CQ DQ E1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 14,391,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,289,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,289,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 14,391,1955

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• RTECS号: UO9100000
• 海关编码: 2934999090

合成路线

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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%