2045-52-5

• 常用中文名：1,2-Ethanediamine,N1,N1-dimethyl-N2-phenyl-N2-(phenylmethyl)-, hydrochloride (1:1)
• 常用英文名：1,2-Ethanediamine,N1,N1-dimethyl-N2-phenyl-N2-(phenylmethyl)-, hydrochloride (1:1)
• CAS号：2045-52-5
• 分子式：C₁₇H₂₃ClN₂
• 分子量：290.83100
• 发布时间：2016-06-09 08:23:03
• 更新时间：2024-04-04 23:15:43

名称

• 英文名: N'-benzyl-N,N-dimethyl-N'-phenylethane-1,2-diamine,hydrochloride
• 英文别名: PHENBENZAMINE HYDROCHLORIDE; 2339 R.P. hydrochloride; Compound 2339 RP; Antergan hydrochloride; N-benzyl-N',N'-dimethyl-N-phenyl-ethylenediamine,hydrochloride; Phenbenzamine chloride; N-Phenyl-N-benzyl-N',N'-dimethylethylenediamine hydrochloride; N-benzyl-N',N'-dimethyl-N-phenyl-ethylenediamine,monohydrochloride; N-Benzyl-N',N'-dimethyl-N-phenyl-aethylendiamin,Monohydrochlorid; N-Benzyl-N',N'-dimethyl-N-phenyl-aethylendiamin,Hydrochlorid; Corps 2339 R P

物化性质

• 沸点: 375.9ºC at 760 mmHg
• 熔点: 210 - 211ºC
• 分子式: C₁₇H₂₃ClN₂
• 分子量: 290.83100
• 闪点: 166.2ºC
• 精确质量: 290.15500
• PSA: 6.48000
• LogP: 4.05680
• 外观性状: 米色结晶粉末
• 蒸汽压: 7.52E-06mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KV1925000 CHEMICAL NAME : Ethylenediamine, N-benzyl-N',N'-dimethyl-N-phenyl-, hydrochloride CAS REGISTRY NUMBER : 2045-52-5 LAST UPDATED : 199109 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C17-H22-N2.Cl-H MOLECULAR WEIGHT : 290.87 WISWESSER LINE NOTATION : 1N1&2NR&1R &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Behavioral - muscle contraction or spasticity REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 68,339,1942 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 144,887,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 325 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,210,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,210,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,210,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,210,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 27,542,1947