CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TU4158100
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CAS REGISTRY NUMBER :
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8067-82-1
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LAST UPDATED :
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199504
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DATA ITEMS CITED :
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7
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MOLECULAR FORMULA :
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C23-H34-O5.C21-H32-O3
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MOLECULAR WEIGHT :
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723.10
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WISWESSER LINE NOTATION :
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L E5 B666 CVTJ A1 E1 FV1OV1 OQ &L E5 B666 CVTJ A1 E1 FV1 OQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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125 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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PRACAK Practitioner. (Morgan-Grampian Ltd., 40 Beresford St., Woolwich, London SE18 6BQ, UK) V.1- 1868- Volume(issue)/page/year: 222,249,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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79 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 32,375,1977
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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36 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 1,119,1975
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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140 mg/kg
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TOXIC EFFECTS :
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Cardiac - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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JEMAAJ Journal of the Egyptian Medical Association. (Egyptian Medical Assoc., 42, Sharia Kasr-El- Aini, Cairo, Egypt) V.11- 1928- Volume(issue)/page/year: 62,191,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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47 mg/kg
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TOXIC EFFECTS :
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Cardiac - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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JEMAAJ Journal of the Egyptian Medical Association. (Egyptian Medical Assoc., 42, Sharia Kasr-El- Aini, Cairo, Egypt) V.11- 1928- Volume(issue)/page/year: 62,191,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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12700 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year: 16,208,1975 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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35 mL/kg
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SEX/DURATION :
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female 9-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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REFERENCE :
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JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 1,165,1975
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