110714-10-8

• 常用中文名：2-{3-[(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)amino]propyl}-3(2H) -pyridazinone hydrochloride (1:1)
• 常用英文名：2-{3-[(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)amino]propyl}-3(2H) -pyridazinone hydrochloride (1:1)
• CAS号：110714-10-8
• 分子式：C₁₆H₂₀ClN₃O₃
• 分子量：337.80100
• 发布时间：2017-02-19 15:42:42
• 更新时间：2024-04-05 08:42:10

名称

• 英文名: 2-{3-[(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)amino]propyl}-3(2H) -pyridazinone hydrochloride (1:1)
• 英文别名: Guvacolinhydrobromid; methyl 1,2,5,6-tetrahydronicotinate hydrobromide; GYKI-12 743; 1,2,5,6-Tetrahydronicotinic Acid Methyl Ester Hydrobromide; norarecoline; 1,2,5,6-Tetrahydro-nicotinic Acid Hydrochloride; 1,2,5,6-Tetrahydro-pyridin-3-carbonsaeure-methylester,Hydrobromid; 1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester hydrobromide; Guvacoline Hydrobromide; Guvacine Methyl Ester Hydrobromide

物化性质

• 沸点: 464.9ºC at 760mmHg
• 分子式: C₁₆H₂₀ClN₃O₃
• 分子量: 337.80100
• 闪点: 235ºC
• 精确质量: 337.11900
• PSA: 65.38000
• LogP: 2.25590
• 蒸汽压: 8.02E-09mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UR6340000 CHEMICAL NAME : 3(2H)-Pyridazinone, 2-(3-(((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)amino )propyl)-, monohydrochloride CAS REGISTRY NUMBER : 110714-10-8 LAST UPDATED : 199806 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C16-H19-N3-O3.Cl-H MOLECULAR WEIGHT : 337.84 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4826845 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 98 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,622,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4826845 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4826845