889877-77-4

• 常用中文名：(7R)-2-氯-7-乙基-7,8-二氢-8-(1-甲基乙基)-6(5H)-蝶啶酮
• 常用英文名：(7R)-2-Chloro-7-ethyl-7,8-dihydro-8-(1-methylethyl)-6(5H)-pteridinone
• CAS号：889877-77-4
• 分子式：C₁₁H₁₅ClN₄O
• 分子量：254.716
• 发布时间：2018-12-29 15:49:22
• 更新时间：2024-01-03 14:59:36

名称

• 中文名: (7R)-2-氯-7-乙基-7,8-二氢-8-(1-甲基乙基)-6(5H)-蝶啶酮
• 英文名: (7R)-2-Chloro-7-ethyl-8-isopropyl-7,8-dihydro-6(5H)-pteridinone
• 英文别名: (7R)-2-Chloro-7-ethyl-7,8-dihydro-8-(1-methylethyl)-6(5H)-pteridinone; (R)-2-chloro-6-(oxiran-2-ylmethoxy)benzonitrile; 2-chloro-1-phenyl ethanol; (R)-2-chloro-1-(m-chlorophenyl)ethanol; (7R)-2-Chloro-7-ethyl-8-isopropyl-7,8-dihydro-6(5H)-pteridinone; 6(5H)-Pteridinone, 2-chloro-7-ethyl-7,8-dihydro-8-(1-methylethyl)-, (7R)-; Benzenemethanol,3-chloro-a-(chloromethyl)-,(aR); 2-chloro-1-(3'-chlorophenyl)ethanol; 2-chloro-6-([(2R)-2-oxiranylmethyl]oxy)benzonitrile; (R)-2-chloro-7-ethyl-8-isopropyl-7,8-dihydropteridin-6(5H)-one; (7R)-2-chloro-7-ethyl-8-isopropyl-7,8-dihydro-5H-pteridin-6-one; (R)-2-chloro-1-phenyl ethanol; (R)-1-(3-chlorophenyl)-2-chloro-1-hydroxyethane; (R)-2-chloro-1-(3-chlorophenyl)ethanol; (7R)-2-chloro-7-ethyl-8-isopropyl-5,7-dihydropteridin-6-one

物化性质

• 密度: 1.224
• 沸点: 465.7±40.0 °C at 760 mmHg
• 分子式: C₁₁H₁₅ClN₄O
• 分子量: 254.716
• 闪点: 235.4±27.3 °C
• 精确质量: 254.093445
• PSA: 61.61000
• LogP: 1.43
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.539
• 储存条件: 2-8°C，避光，保存于惰性气体中

合成路线

946161-16-6 ~89% 889877-77-4

文献：BOEHRINGER INGELHEIM INTERNATIONAL GMBH Patent: WO2009/19205 A1, 2009 ; Location in patent: Page/Page column 13-14 ;

947667-22-3 ~% 889877-77-4

文献：Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co. Ltd. Patent: EP2481739 A1, 2012 ;

946161-16-6 64-19-7 ~% 889877-77-4

文献：Bowers, Simeon; Truong, Anh P.; Ye, Michael; Aubele, Danielle L.; Sealy, Jennifer M.; Neitz, R. Jeffrey; Hom, Roy K.; Chan, Wayman; Dappen, Michael S.; Galemmo Jr., Robert A.; Konradi, Andrei W.; Sham, Hing L.; Zhu, Yong L.; Beroza, Paul; Tonn, George; Zhang, Heather; Hoffman, Jennifer; Motter, Ruth; Fauss, Donald; Tanaka, Pearl; Bova, Michael P.; Ren, Zhao; Tam, Danny; Ruslim, Lany; Baker, Jeanne; Pandya, Deepal; Diep, Linnea; Fitzgerald, Kent; Artis, Dean R.; Anderson, John P.; Bergeron, Marcelle Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2743 - 2749

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