116169-42-7

• 常用中文名：3-Quinolinecarboxylic acid, 1,4-dihydro-7-(3-amino-3-phenyl-1-pyrrolid inyl)-1-cyclopropyl-6,8-difluoro-4-oxo-
• 常用英文名：3-Quinolinecarboxylic acid, 1,4-dihydro-7-(3-amino-3-phenyl-1-pyrrolid inyl)-1-cyclopropyl-6,8-difluoro-4-oxo-
• CAS号：116169-42-7
• 分子式：C₂₃H₂₁F₂N₃O₃
• 分子量：425.42800
• 发布时间：2016-03-13 12:06:35
• 更新时间：2024-01-20 21:05:13

名称

• 英文名: 7-(3-amino-3-phenylpyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
• 英文别名: Enrofloxacin Imp. G (EP),HCl; Desethylene Ciprofloxacin,Hydrochloride; 7-[(2-amino-ethyl)amino]-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-quinoline-3-carboxylic acid hydrochloride; 7-[(3-amino-3-phenyl)-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; BAY-r 3964,M1-Ciprofloxacin,7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

物化性质

• 密度: 1.48g/cm3
• 沸点: 630ºC at 760mmHg
• 分子式: C₂₃H₂₁F₂N₃O₃
• 分子量: 425.42800
• 闪点: 334.8ºC
• 精确质量: 425.15500
• PSA: 88.56000
• LogP: 4.14240
• 蒸汽压: 9.76E-17mmHg at 25°C
• 折射率: 1.673

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VB1987200 CHEMICAL NAME : 3-Quinolinecarboxylic acid, 1,4-dihydro-7-(3-amino-3-phenyl-1-pyrrolidinyl)-1-cyc lopropyl-6,8-difluoro -4-oxo- CAS REGISTRY NUMBER : 116169-42-7 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C23-H21-F2-N3-O3 MOLECULAR WEIGHT : 425.47 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Micronucleus test TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 50 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 298,227,1993

合成路线

116169-48-3 94695-52-0 6674-22-2 ~% 116169-42-7

文献：Warner-Lambert Company Patent: US4840956 A1, 1989 ;

116169-48-3 94695-52-0 ~82% 116169-42-7

文献：Hagen; Domagala; Heifetz; Sanchez; Solomon Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 849 - 854

1865-29-8 ~% 116169-42-7

文献：Hagen; Domagala; Heifetz; Sanchez; Solomon Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 849 - 854

124563-09-3 ~% 116169-42-7

文献：Hagen; Domagala; Heifetz; Sanchez; Solomon Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 849 - 854

124562-89-6 ~% 116169-42-7

文献：Hagen; Domagala; Heifetz; Sanchez; Solomon Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 849 - 854

124562-92-1 ~% 116169-42-7

文献：Hagen; Domagala; Heifetz; Sanchez; Solomon Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 849 - 854

124562-91-0 ~% 116169-42-7

文献：Hagen; Domagala; Heifetz; Sanchez; Solomon Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 849 - 854

上下游产品

上游产品  5
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