138304-93-5

• 常用中文名：1,8-Naphthyridine-3-carboxamide, 1,2-dihydro-N-(2-(dimethylamino)ethyl )-4-hydroxy-2-oxo-1-phenyl-
• 常用英文名：1,8-Naphthyridine-3-carboxamide, 1,2-dihydro-N-(2-(dimethylamino)ethyl )-4-hydroxy-2-oxo-1-phenyl-
• CAS号：138304-93-5
• 分子式：C₁₉H₂₀N₄O₃
• 分子量：352.38700
• 发布时间：2016-10-24 13:24:17
• 更新时间：2024-02-04 06:50:17

名称

• 英文名: N-[2-(dimethylamino)ethyl]-4-hydroxy-2-oxo-1-phenyl-1,8-naphthyridine-3-carboxamide

物化性质

• 密度: 1.333g/cm3
• 沸点: 539.6ºC at 760mmHg
• 分子式: C₁₉H₂₀N₄O₃
• 分子量: 352.38700
• 闪点: 280.1ºC
• 精确质量: 352.15400
• PSA: 87.46000
• LogP: 1.77360
• 蒸汽压: 1.78E-12mmHg at 25°C
• 折射率: 1.648

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QN2790590 CHEMICAL NAME : 1,8-Naphthyridine-3-carboxamide, 1,2-dihydro-N-(2-(dimethylamino)ethyl)-4-hydroxy-2-ox o-1- phenyl- CAS REGISTRY NUMBER : 138304-93-5 LAST UPDATED : 199806 DATA ITEMS CITED : 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5126341 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5126341

合成路线

138305-20-1 108-00-9 ~64% 138304-93-5

文献：Kuroda; Suzuki; Tamura; Ohmori; Hosoe Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1130 - 1136

138305-19-8 ~% 138304-93-5

文献：Kuroda; Suzuki; Tamura; Ohmori; Hosoe Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1130 - 1136