188936-07-4

• 常用中文名：(3S,4aS,8aS)-2-[(2R)-2-[(4S)-2-[3-羟基-2-甲基苯基]-4,5-二氢恶唑-4-基]-2-羟乙基]十氢异喹啉-3-甲酸叔丁酰胺
• 常用英文名：2-HYDROXY-4-PYRIDINECARBOXALDEHYDE
• CAS号：188936-07-4
• 分子式：C₂₆H₃₉N₃O₄
• 分子量：457.60600
• 发布时间：2018-12-05 15:59:18
• 更新时间：2024-01-08 20:15:11

名称

• 中文名: (3S,4aS,8aS)-2-[(2R)-2-[(4S)-2-[3-羟基-2-甲基苯基]-4,5-二氢恶唑-4-基]-2-羟乙基]十氢异喹啉-3-甲酸叔丁酰胺
• 英文名: (3S,4aS,8aS)-2-[(2R)-2-[(4S)-2-[3-Hydroxy-2-methylphenyl]-4,5-dihydrooxazol-4-yl]-2-hydroxyethyl]decahydroisoquinoline-3-carboxylic acid tert-butylamide
• 中文别名: 奈非那韦恶唑杂质
• 英文别名: (3S,4AS,8AS)-2-[(2R)-2-[(4S)-2-[3-Hydroxy-2-Methylphenyl]-4,5-Dihydrooxazol-4-Yl]-2-Hydroxyethyl]Decahydro-iso-Quinoline-3-Carboxylic Acid T-Butyrylamide; (3S,4aS,8aS)-2-[(2R)-2-[(4S)-4,5-Dihydro-2-(3-hydroxy-2-methylphenyl)-4-oxazolyl]-2-hydroxyethyl]-N-(1,1-dimethylethyl)decahydro-3-isoquinolinecarboxamide; (3S,4aS,8aS)-2-{(2R)-2-[(4S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl]-2-hydroxyethyl}decahydroisoquinoline-3-carboxylic acid t-butylamide

物化性质

• 密度: 1.28
• 沸点: 684.539ºC at 760 mmHg
• 分子式: C₂₆H₃₉N₃O₄
• 分子量: 457.60600
• 闪点: 367.796ºC
• 精确质量: 457.29400
• PSA: 94.39000
• LogP: 2.76670
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.623

合成路线

188936-06-3 ~58% 188936-07-4

文献：Japan Tobacco Inc.; Agouron Pharmaceuticals, Inc. Patent: US6133461 A1, 2000 ;

128019-40-9 188936-06-3 ~% 188936-07-4

文献：Inaba, Takashi; Birchler, Angela G.; Yamada, Yasuki; Sagawa, Shoichi; Yokota, Katsuyuki; Ando, Koji; Uchida, Itsuo Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7582 - 7583

167678-46-8 ~% 188936-07-4

文献：Zook; Busse; Borer Tetrahedron Letters, 2000 , vol. 41, # 36 p. 7017 - 7021

188936-02-9 ~% 188936-07-4

文献：Inaba, Takashi; Birchler, Angela G.; Yamada, Yasuki; Sagawa, Shoichi; Yokota, Katsuyuki; Ando, Koji; Uchida, Itsuo Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7582 - 7583

188936-03-0 ~% 188936-07-4

文献：Inaba, Takashi; Birchler, Angela G.; Yamada, Yasuki; Sagawa, Shoichi; Yokota, Katsuyuki; Ando, Koji; Uchida, Itsuo Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7582 - 7583

128019-40-9 201402-95-1 ~% 188936-07-4

文献：Albizati, Kim F.; Babu, Srinivasan; Birchler, Angela; Busse, Juliette K.; Fugett, Michelle; Grubbs, Alan; Haddach, Aubrey; Pagan, Miguel; Potts, Barbara; Remarchuk, Travis; Rieger, Dale; Rodriguez, Rick; Shanley, Jim; Szendroi, Robert; Tibbetts, Tony; Whitten, Kathleen; Borer, Bennett C. Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6481 - 6485