33453-23-5

• 常用中文名：环丙喹宗
• 常用英文名：Ciproquazone
• CAS号：33453-23-5
• 分子式：C₁₉H₁₈N₂O₂
• 分子量：306.35800
• 发布时间：2018-07-08 13:22:38
• 更新时间：2024-01-14 17:44:14
• Ciproquazone 具有镇痛活性,可用于治疗脊柱炎。

名称

• 中文名: 环丙喹宗
• 英文名: 1-(cyclopropylmethyl)-6-methoxy-4-phenylquinazolin-2-one
• 英文别名: 1-Cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-chinazolinon; 1-Cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-quinazolinone; 1-cyclopropylmethyl-6-methoxy-4-phenyl-1H-quinazolin-2-one; Ciproquazonum [INN-Latin]; CIPROQUAZONE; SL-573; Ciproquazona; 1-(Cyclopropyl-methyl)-4-phenyl-6-methoxy-1H-chinazolinon-(2); 2(1H)-Quinazolinone,1-(cyclopropylmethyl)-6-methoxy-4-phenyl; 1-(Cyclopropylmethyl)-6-methoxy-4-phenyl-2(1H)-quinazolinone; Ciproquazona [INN-Spanish]

物化性质

• 密度: 1.26g/cm3
• 沸点: 483.8ºC at 760mmHg
• 分子式: C₁₉H₁₈N₂O₂
• 分子量: 306.35800
• 闪点: 246.4ºC
• 精确质量: 306.13700
• PSA: 44.12000
• LogP: 3.48210
• 折射率: 1.653

生物活性

• 描述: Ciproquazone 具有镇痛活性,可用于治疗脊柱炎。
• 参考文献: 1. Vega S, et al. Thiophene isosteres: synthesis and biological evaluation of 3-substituted derivatives of 4-phenyl-2-thioxo-benzo [4, 5] thieno [2, 3-d] pyrimidine. European journal of medicinal chemistry, 1991, 26(3): 323-329.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA3100333 CHEMICAL NAME : 2(1H)-Quinazolinone, 1-(cyclopropylmethyl)-6-methoxy-4-phenyl- CAS REGISTRY NUMBER : 33453-23-5 BEILSTEIN REFERENCE NO. : 0761592 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C19-H18-N2-O2 MOLECULAR WEIGHT : 306.39 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 gm/kg/30D-I TOXIC EFFECTS : Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in testicular weight REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1991,1979 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9100 mg/kg/13W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1991,1979

合成路线

95-50-1 36942-71-9 ~% 33453-23-5

文献：Sumitomo Chemical Company, Limited Patent: US4387223 A1, 1983 ;

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