CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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YS5075000
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CHEMICAL NAME :
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Urea, 1-(2-chloroethyl)-1-nitroso-3-(2-norbornyl)-
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CAS REGISTRY NUMBER :
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13909-13-2
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C10-H16-Cl-N3-O2
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MOLECULAR WEIGHT :
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245.74
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WISWESSER LINE NOTATION :
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L55 ATJ CMVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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83 mg/kg
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TOXIC EFFECTS :
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Liver - jaundice, other or unclassified Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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56 mg/kg
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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54760 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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18750 ug/kg/15D-I
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TOXIC EFFECTS :
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Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
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REFERENCE :
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NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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15 mg/kg/5W-I
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TOXIC EFFECTS :
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Liver - change in gall bladder structure or function Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
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REFERENCE :
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NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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35 mg/kg/15D-I
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TOXIC EFFECTS :
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Liver - fatty liver degeneration Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
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