3188-46-3

• 常用中文名：雌二醇
• 常用英文名：β-Estradiol
• CAS号：3188-46-3
• 分子式：C₁₈H₂₂D₂O₂
• 分子量：274.39
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-06-14 15:41:07
• 更新时间：2024-01-03 20:23:35
• 雌二醇-d2-1是氘标记的雌二醇。雌二醇是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。雌二醇通过雌激素受体β(ERβ)途径上调IL-6的表达[1][2][3][4]。

名称

• 中文名: 17B-雌二醇-D2
• 英文名: 17beta-estradiol-16,16-d2
• 中文别名: 雌二醇
• 英文别名: 17b-OH-estradiol; Estradiol-17β; nb-15N nitrobenzene; 17b-Estradiol; Epiestriol 50; Estra-1,3,5(10)-triene-3,17-diol, (17β)-; 17β estradiol; δ-Estradiol; Destradiol; Estradiol-17 β; Oestra-1,3,5(10)-triene-3,17β-diol; 17b-Oestra-1,3,5(10)-triene-3,17-diol; Estra-1(10),2,4-triene-3,17-diol, (17β)-; δ-Oestradiol; estra-1(10),2,4-triene-3,17-diol, (17b)-; Oestradiol-17b; 3,17β-Dihydroxyestra-1,3,5(10)-triene; D-3,17b-Estradiol; estradiol 17b; Ovocylin; nitromethane-15N; (17b)-Estra-1,3,5(10)-triene-3,17-diol; 3,17β-Estradiol; 3,17b-Dihydroxyestra-1,3,5(10)-triene; 17-β-estradiol; 3,17b-Oestradiol; Oestrogel; B-Estradiol; Estradiol-17-β; 17-β-OH-estradiol; D-3,17b-Oestradiol; Estrogel; nitrobenzene-15N; Oestra-1,3,5(10)-triene-3,17b-diol; Estradiolum; 3,17b-Dihydroxy-1,3,5(10)-oestratriene; Estradiol; Estradiol, β-; Estradiol-17b; 15N-nitromethane; 17b-Oestradiol; (+)-3,17b-Estradiol; 17β-estradiol; (17β)-Estra-1(10),2,4-triene-3,17-diol; Estradiolo [DCIT]; Nitromethan-<15-N>; 17β estradiol (E2); D-3,17β-Estradiol; 17b-OH-oestradiol; 17β-OH-oestradiol; 17-β-OH-oestradiol; 13β-Methyl-1,3,5(10)-gonatriene-3,17β-ol; Estra-1,3,5(10)-triene-3,17b-diol; 3,17b-Estradiol; Oestradiol-17β; FEMPATCH; (8R,9S,13S,14S,17S)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3,17-diol; 13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol; Estracomb TTS; Estradiol-3,17b; (17b)-estra-1(10),2,4-triene-3,17-diol; Profoliol B; (+)-3,17β-Estradiol; 17β-OH-estradiol; 17β-Oestradiol

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 445.9±45.0 °C at 760 mmHg
• 分子式: C₁₈H₂₂D₂O₂
• 分子量: 274.39
• 闪点: 209.6±23.3 °C
• 精确质量: 272.177643
• PSA: 40.46000
• LogP: 4.13
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.599
• 储存条件: -20°C

生物活性

• 描述: 雌二醇-d2-1是氘标记的雌二醇。雌二醇是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。雌二醇通过雌激素受体β(ERβ)途径上调IL-6的表达[1][2][3][4]。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59.

  [3]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604.

  [4]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133.

  [5]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.

  [6]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

  [7]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.

合成路线

53-16-7 ~% 3188-46-3

文献：Debrauwer, Laurent; Paris, Alain; Rao, Dinesh; Fournier, Francoise; Tabet, Jean-Claude Organic Mass Spectrometry, 1992 , vol. 27, # 6 p. 709 - 719

56588-58-0 ~% 3188-46-3

文献：Debrauwer, Laurent; Paris, Alain; Rao, Dinesh; Fournier, Francoise; Tabet, Jean-Claude Organic Mass Spectrometry, 1992 , vol. 27, # 6 p. 709 - 719

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