63989-75-3

• 常用中文名：Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
• 常用英文名：Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
• CAS号：63989-75-3
• 分子式：C₂₇H₂₇NO₆
• 分子量：461.50600
• 发布时间：2016-01-10 07:39:09
• 更新时间：2024-02-07 16:26:20

名称

• 英文名: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]benzamide
• 英文别名: N-Benzoyltrimethylcolchicinsaeuremethylaether; N-Benzoyl-deacetylcolchicine; Colchicine,N-benzoyl-N-deacetyl; N-Benzoyl trimethyl colchicinic acid methyl ether; N-Benzoyl tmca methyl ether; COLCHICINE,N-DEACETYL-N-BENZOYL; N-benzoyl-N-deacetylcolchicine

物化性质

• 密度: 1.28g/cm3
• 沸点: 780.3ºC at 760 mmHg
• 分子式: C₂₇H₂₇NO₆
• 分子量: 461.50600
• 闪点: 425.7ºC
• 精确质量: 461.18400
• PSA: 83.09000
• LogP: 4.55640
• 折射率: 1.62
• 储存条件: 通风低温干燥,与库房食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0790000 CHEMICAL NAME : Colchicine, N-deacetyl-N-benzoyl- CAS REGISTRY NUMBER : 63989-75-3 BEILSTEIN REFERENCE NO. : 3184511 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C27-H27-N-O6 MOLECULAR WEIGHT : 461.55 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JMVR& NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 27 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 27924 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 12500 ug/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Gastrointestinal - other changes TYPE OF TEST : Mutation test systems - not otherwise specified TYPE OF TEST : Mutation test systems - not otherwise specified MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 32 mg/kg REFERENCE : CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950

合成路线

3476-50-4 93-97-0 ~% 63989-75-3

文献：Brossi; Sharma; Atwell; Jacobson; Iorio; Molinari; Chignell Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1365 - 1369

186581-53-3 14686-58-9 ~% 63989-75-3

文献：Santavy Chemicke Listy, 1952 , vol. 46, p. 280,284 Chem.Abstr., 1953 , p. 4325

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