前往化源商城

入驻化源商城

品牌现货直购

上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：盐酸二氧丙嗪
纯度：98.0%
规格：
联系人：徐经理
联系电话：13311869306

南通润丰石油化工有限公司
江苏省南通市崇川区
产品名：盐酸二氧丙嗪
纯度：99.0%
规格：1kg/25kg/200kg
联系人：曹经理
联系电话：17625439817

湖北魏氏化学试剂股份有限公司
湖北省武汉市洪山区
产品名：盐酸二氧丙嗪；克咳敏
纯度：98.0%
规格：5mg/25mg/10g/50g
联系人：张栋
联系电话：18717199209

武汉鼎信通药业有限公司
湖北省武汉市江夏区
产品名：克咳敏/盐酸二氧丙嗪
纯度：99.0%
规格：1kg
联系人：董浩
联系电话：13429867250

查看所有供应商和价格请点击：

13754-56-8生产厂家

13754-56-8价格

13754-56-8

13754-56-8结构式

常用中文名：盐酸二氧丙嗪
常用英文名：Dioxopromethazine
CAS号：13754-56-8
分子式：C₁₇H₂₀N₂O₂S
分子量：316.418
相关类别：原料药抗变态反应药抗组胺药
发布时间：2018-09-07 16:51:33
更新时间：2024-01-09 14:07:04
二氧丙嗪是一种口服活性抗组胺药。二氧丙嗪抑制哮喘症状[1]。

化源商城直购

中文名	盐酸二氧丙嗪
英文名	1-(5,5-dioxophenothiazin-10-yl)-N,N-dimethylpropan-2-amine
中文别名	10-(2-二甲氨基-异丙基)吩噻嗪-5,5-二氧化物的盐酸盐二氧丙嗪
英文别名	UNII:6OOT1MR6XS 9,9-Dioxypromethazin 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, 5,5-dioxide (9CI) 9,9-Dioxopromethazine 1-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N-dimethyl-2-propanamine Promethazine SS oxide Dioxopromethazine Promethazine 5,5-dioxide Prothanon 1-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N-dimethylpropan-2-amine 9,9-Dioxopromethazin 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, 5,5-dioxide

描述	二氧丙嗪是一种口服活性抗组胺药。二氧丙嗪抑制哮喘症状[1]。
相关类别	信号通路 >> 免疫及炎症 >> 组胺受体研究领域 >> 炎症/免疫信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
参考文献	[1]. Bartsch R, et al. Zur Pharmakologie des neuen Antihistaminicums 9.9-Dioxopromethazin (Prothanon) [Pharmacology of the new antihistaminic 9,9-dioxopromethazine (Prothanon)]. Pharmazie. 1970;25(2):91-96.

密度	1.2±0.1 g/cm3
沸点	478.5±34.0 °C at 760 mmHg
熔点	127-129ºC
分子式	C₁₇H₂₀N₂O₂S
分子量	316.418
闪点	243.2±25.7 °C
精确质量	316.124542
PSA	49.00000
LogP	2.18
蒸汽压	0.0±1.2 mmHg at 25°C
折射率	1.606
储存条件	室温

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO7350000

CHEMICAL NAME :: Phenothiazine, 10-(2-(dimethylamino)propyl)-, 5,5-dioxide, monohydrochloride

CAS REGISTRY NUMBER :: 13754-56-8

LAST UPDATED :: 199503

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C17-H20-N2-O2-S.Cl-H

MOLECULAR WEIGHT :: 352.91

WISWESSER LINE NOTATION :: T C666 BN ISWJ B3N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,155,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 49 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 96 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,155,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970