163521-12-8

• 常用中文名：维拉佐酮
• 常用英文名：Vilazodone
• CAS号：163521-12-8
• 分子式：C₂₆H₂₇N₅O₂
• 分子量：441.52
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-06-08 17:44:52
• 更新时间：2024-01-02 13:44:05
• Vilazodone(EMD 68843; SB 659746A)是五羟色胺重吸收抑制剂(SSRI)和5-HT1A受体部分激动剂。

名称

• 中文名: 维拉佐酮
• 英文名: vilazodone
• 中文别名: 维拉佐酮; 维拉唑酮
• 英文别名: 5-{4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl}-1-benzofuran-2-carboxamide; 2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-; Viibryd; 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide; 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide; 5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide; vilazodone

物化性质

• 密度: 1.34 g/cm3
• 沸点: 745.1ºC at 760 mmHg
• 熔点: 203-205ºC
• 分子式: C₂₆H₂₇N₅O₂
• 分子量: 441.52
• PSA: 102.29000
• LogP: 5.53478
• 外观性状: 淡黄色固体
• 储存条件: -20°C

生物活性

• 描述: Vilazodone(EMD 68843; SB 659746A)是五羟色胺重吸收抑制剂(SSRI)和5-HT1A受体部分激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Cruz MP. Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31.

  [2]. Citrome L. Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J C

  [3]. Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME. The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder. Curr Med Res Opin. 2012 Jan;28(1):27-39.

  [4]. Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009

  [5]. Thomas L. Schwartz Vilazodone: a brief pharmacological and clinical review of the novel serotonin partial agonist and reuptake inhibitor Therapeutic Advances in Psychopharmacology June 2011 vol. 1 no. 3 81-87

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