135-44-4

• 常用中文名：亮氨卡因
• 常用英文名：2-(diethylamino)-4-methylpentyl 4-aminobenzoate, monomethanesulphonate
• CAS号：135-44-4
• 分子式：C₁₈H₃₂N₂O₅S
• 分子量：388.52200
• 发布时间：2018-09-22 13:32:17
• 更新时间：2024-01-11 18:19:02

名称

• 中文名: 亮氨卡因
• 英文名: 2-(diethylamino)-4-methylpentyl 4-aminobenzoate, monomethanesulphonate
• 英文别名: 2-Diethylamino-4-methyl-1-pentanol 4-aminobenoate monomethanesulfonate; 4-Amino-benzoesaeure-(2-diaethylamino-4-methyl-pentylester),Methansulfonat; 4-amino-benzoic acid-(2-diethylamino-4-methyl-pentylester),methanesulfonate; Leucinocaine methanesulfonate; monomethanesulfonate (salt); Leucinocainmesilat; Leucinocaine; Leucinocaine mesylate; Panthesine; 2-(diethylamino)-4-methyl-1-pentanol; monomethanesulfonate; EINECS 205-191-6; Panthesin; 4-aminobenzoate (ester)

物化性质

• 沸点: 417.1ºC at 760mmHg
• 分子式: C₁₈H₃₂N₂O₅S
• 分子量: 388.52200
• 闪点: 206ºC
• 精确质量: 388.20300
• PSA: 118.31000
• LogP: 4.34810
• 蒸汽压: 3.65E-07mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SA6475000 CHEMICAL NAME : 1-Pentanol, 2-(diethylamino)-4-methyl-, p-aminobenzoate (ester), monomethanesulfonate CAS REGISTRY NUMBER : 135-44-4 LAST UPDATED : 199012 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C17-H28-N2-O2.C-H4-O3-S MOLECULAR WEIGHT : 388.58 WISWESSER LINE NOTATION : ZR DVO1YN2&2&1Y1&1 &OSW1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 49 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic REFERENCE : WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 57,221,1936 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraspinal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 10200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 54,137,1935 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 112 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

安全

• 海关编码: 2922499990

海关

海关编码	2922499990
中文概述	2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%