19879-06-2

• 常用中文名：8,11-Ethanofuro[2,3-e]naphtho[2,3-c:6,7-c']dipyran-2,6,13(9H)-trione,3,3a,5,8,11,13b-hexahydro-7,8,12,15-tetrahydroxy-5,9-dimethyl-,(3aS,5S,8S,9R,11R,13bS,15R)-
• 常用英文名：8,11-Ethanofuro[2,3-e]naphtho[2,3-c:6,7-c']dipyran-2,6,13(9H)-trione,3,3a,5,8,11,13b-hexahydro-7,8,12,15-tetrahydroxy-5,9-dimethyl-,(3aS,5S,8S,9R,11R,13bS,15R)-
• CAS号：19879-06-2
• 分子式：C₂₂H₂₀O₁₀
• 分子量：444.38800
• 发布时间：2017-03-22 22:33:39
• 更新时间：2024-01-07 17:15:12

名称

• 英文名: granaticin
• 中文别名: 榴菌素A
• 英文别名: Antibiotic WR 141; WR-141; (3aS)-7,8,12,15syn-Tetrahydroxy-5c,9c-dimethyl-(3ar,13bc)-3,3a,5,8,11,13b-hexahydro-9H-8t,11t-aethano-furo[3,2-c]isochromeno[7,6-g]isochromen-2,6,13-trion; (3aS)-7,8,12,15syn-tetrahydroxy-5c,9c-dimethyl-(3ar,13bc)-3,3a,5,8,11,13b-hexahydro-9H-8t,11t-ethano-furo[3,2-c]isochromeno[7,6-g]isochromene-2,6,13-trione; Granaticin A; Antibiotic WR-141; Litmomycin; Granatcin-A; Granatomycin C

物化性质

• 密度: 1.77g/cm3
• 沸点: 748.3ºC at 760mmHg
• 分子式: C₂₂H₂₀O₁₀
• 分子量: 444.38800
• 闪点: 266.8ºC
• 精确质量: 444.10600
• PSA: 159.82000
• LogP: 0.28820
• 蒸汽压: 1.6E-23mmHg at 25°C
• 折射率: 1.745

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MD9100000 CHEMICAL NAME : Granaticin CAS REGISTRY NUMBER : 19879-06-2 LAST UPDATED : 199512 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C22-H20-O10 MOLECULAR WEIGHT : 444.42 WISWESSER LINE NOTATION : T F5 E6 C6666/RW 2AQ W DV GOV KO NV TOTT&&TTJ BQ L1 PQ RQ S1 WQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 14 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 38 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 600 nmol/L REFERENCE : ZBPHA6 Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung I: Medizinisch-Hygienische Bakteriologie, Virusforschung und Parasitologie, Originale. (Stuttgart, Fed. Rep. Ger.) V.31-216, 1902-71. For publisher information, see ZMMPAO. Volume(issue)/page/year: 212,259,1969

合成路线

108168-52-1 ~% 19879-06-2

文献：Nomura; Okazaki; Hori; Yoshii Journal of the American Chemical Society, 1987 , vol. 109, # 11 p. 3402 - 3408

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