89567-03-3

• 常用中文名：5,6,7,8-四氢-2-氯甲基-(1)苯并噻吩(2,3-d)嘧啶-4(1H)-酮
• 常用英文名：3-d)pyrimidin-4(1h)-one,5,6,7,8-tetrahydro-2-(chloromethyl)-(1)benzothieno(
• CAS号：89567-03-3
• 分子式：C₁₁H₁₁ClN₂OS
• 分子量：254.73600
• 发布时间：2018-12-23 14:06:59
• 更新时间：2024-01-05 22:06:32

名称

• 中文名: 5,6,7,8-四氢-2-氯甲基-(1)苯并噻吩(2,3-d)嘧啶-4(1H)-酮
• 英文名: 2-(chloromethyl)-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-4-one
• 英文别名: 5,5-Dimethyl-2-chlormethyl-1,3-dioxan; 5,5-Dimethyl-2-chlormethyl-m-dioxan; 2-chloromethyl-5,5-dimethyl-1,3-dioxane

物化性质

• 密度: 1.64g/cm3
• 分子式: C₁₁H₁₁ClN₂OS
• 分子量: 254.73600
• 精确质量: 254.02800
• PSA: 74.25000
• LogP: 3.01450
• 折射率: 1.781

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DL8354500 CHEMICAL NAME : (1)Benzothieno(2,3-d)pyrimidin-4(1H)-one, 5,6,7,8-tetrahydro-2-(chloromethyl)- CAS REGISTRY NUMBER : 89567-03-3 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C11-H11-Cl-N2-O-S MOLECULAR WEIGHT : 254.75 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >9 gm/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes Musculoskeletal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 40,567,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes Musculoskeletal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 40,567,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3500 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes Musculoskeletal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 40,567,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 gm/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes Musculoskeletal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 40,567,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes Musculoskeletal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 40,567,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2600 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes Musculoskeletal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 40,567,1990

安全

• 海关编码: 2934999090

合成路线

4506-71-2 107-14-2 ~87% 89567-03-3

文献：Jain, Kishor S.; Bariwal, Jitender B.; Phoujdar, Manisha S.; Nagras, Madhuri A.; Amrutkar, Rakesh D.; Munde, Manoj K.; Tamboli, Riyaj S.; Khedkar, Samrat A.; Khiste, Rahul H.; Vidyasagar, Nikhil C.; Dabholkar, Vinit V.; Kathiravan Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 178 - 185

20886-87-7 ~83% 89567-03-3

文献：Kanwar, Seema; Sharma Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2367 - 2371

108-94-1 ~% 89567-03-3

文献：Kanwar, Seema; Sharma Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2367 - 2371

4815-28-5 ~% 89567-03-3

文献：Kanwar, Seema; Sharma Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2367 - 2371

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%