(33R,35S,91R,92R,5S)-5-(叔丁基)-17-甲氧基-4,7-二氧基-2,8-二氧基-6-氮杂-1(2,3)-喹恶啉-3(3,1)-吡咯烷-9(1,2)-环丙烷环己基-35-羧酸

• 常用名: (33R,35S,91R,92R,5S)-5-(叔丁基)-17-甲氧基-4,7-二氧基-2,8-二氧基-6-氮杂-1(2,3)-喹恶啉-3(3,1)-吡咯烷-9(1,2)-环丙烷环己基-35-羧酸
• 英文名: MK-5172
• CAS号: 1206524-85-7
• 分子量: 554.635
• 密度: 1.3±0.1 g/cm3
• 沸点: 825.0±65.0 °C at 760 mmHg
• 分子式: C₂₉H₃₈N₄O₇
• 熔点: N/A
• 闪点: 452.7±34.3 °C

用途

MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development.

名称

• 中文名: (33R,35S,91R,92R,5S)-5-(叔丁基)-17-甲氧基-4,7-二氧基-2,8-二氧基-6-氮杂-1(2,3)-喹恶啉-3(3,1)-吡咯烷-9(1,2)-环丙烷环己基-35-羧酸
• 英文名: (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid

物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 825.0±65.0 °C at 760 mmHg
• 分子式: C₂₉H₃₈N₄O₇
• 分子量: 554.635
• 闪点: 452.7±34.3 °C
• 精确质量: 554.274048
• PSA: 143.67000
• LogP: 4.64
• 蒸汽压: 0.0±3.1 mmHg at 25°C
• 折射率: 1.616
• 储存条件: -20°C，干燥密封

英文别名

• S1492_Selleck
• (1R,18R,20R,24S,27S)-7-Methoxy-24-(2-methyl-2-propanyl)-22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo[24.2.1.0.0.0]nonacosa-3,5,7,9,11-pentaene-27-carboxylic acid
• 8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-, (1aS,5S,8S,10R,22aR)-
• 8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-, (1aR,5S,8S,10R,22aR)-
• (1R,18R,20S,24S,27S)-7-Methoxy-24-(2-methyl-2-propanyl)-22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo[24.2.1.0.0.0]nonacosa-3,5(10),6,8,11-pentaene-27-carboxylic acid
• UNII-RU4QU6O6X6
• MK-5172
• Grazoprevir