(Rac)-SNC80

• 常用名: (Rac)-SNC80
• 英文名: (Rac)-SNC80
• CAS号: 1217643-87-2
• 分子量: 449.63
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₉N₃O₂
• 熔点: N/A
• 闪点: N/A

(Rac)-SNC80用途

(Rac)-SNC80是SNC80(HY-101202)的外消旋体。SNC80(NIH 10815)是一种强效、高选择性和非肽δ-阿片受体激动剂,Ki为1.78 nM,IC50为2.73 nM。SNC80显示出抗伤害性、抗高血压和抗抑郁作用。SNC80具有治疗多种头痛障碍的潜力[1][2][3][4][5][6]。

(Rac)-SNC80名称

• 英文名: (Rac)-SNC80

(Rac)-SNC80生物活性

• 描述: (Rac)-SNC80是SNC80(HY-101202)的外消旋体。SNC80(NIH 10815)是一种强效、高选择性和非肽δ-阿片受体激动剂,Ki为1.78 nM,IC50为2.73 nM。SNC80显示出抗伤害性、抗高血压和抗抑郁作用。SNC80具有治疗多种头痛障碍的潜力[1][2][3][4][5][6]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Moye LS, et al. Delta opioid receptor agonists are effective for multiple types of headache disorders. Neuropharmacology. 2019 Apr;148:77-86.

  [2]. Bilsky EJ, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J Pharmacol Exp Ther. 1995 Apr;273(1):359-66.

  [3]. Calderon SN, et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. J Med Chem. 1994 Jul 8;37(14):2125-8.

  [4]. Metcalf MD, et al. The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9.

  [5]. Vicente-Sanchez A, et al. The delta opioid receptor tool box. Neuroscience. 2016 Dec 3;338:145-159.

  [6]. Dripps IJ, et al. Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80. Br J Pharmacol. 2018 Mar;175(6):891-901.

(Rac)-SNC80物理化学性质

• 分子式: C₂₈H₃₉N₃O₂
• 分子量: 449.63