盐酸昂丹司琼-d6

• 常用名: 盐酸昂丹司琼-d6
• 英文名: Ondansetron-d6 hydrochloride
• CAS号: 1225442-22-7
• 分子量: 335.86
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₄D₆ClN₃O
• 熔点: N/A
• 闪点: N/A

盐酸昂丹司琼-d6用途

昂丹司琼-6(盐酸)是氘标记的盐酸昂丹司酮[1]。盐酸昂丹司琼是一种5-羟色胺5-HT3受体拮抗剂,主要用作止吐剂(治疗恶心和呕吐),通常在化疗后使用[2][3][4][5][6][7]。

盐酸昂丹司琼-d6名称

• 中文名: 盐酸昂丹司琼-d6
• 英文名: Ondansetron-d6 hydrochloride

盐酸昂丹司琼-d6生物活性

• 描述: 昂丹司琼-6(盐酸)是氘标记的盐酸昂丹司酮[1]。盐酸昂丹司琼是一种5-羟色胺5-HT3受体拮抗剂,主要用作止吐剂(治疗恶心和呕吐),通常在化疗后使用[2][3][4][5][6][7]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 体外研究: 氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

  [2]. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.

  [3]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep362(3):255-65.

  [4]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 11300:41-50.

  [5]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov20(6):1103-16.

  [6]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb20(1):78-83.

  [7]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May12(3):421-31.

盐酸昂丹司琼-d6物理化学性质

• 分子式: C₁₈H₁₄D₆ClN₃O
• 分子量: 335.86