N-(2'-(S)-羟基花生四烯基)-D-赤型鞘氨醇

• 常用名: N-(2'-(S)-羟基花生四烯基)-D-赤型鞘氨醇
• 英文名: N-(2'-(S)-hydroxyarachidoyl)-D-erythro sphingosine
• CAS号: 1246298-48-5
• 分子量: 610.006
• 密度: 0.9±0.1 g/cm3
• 沸点: 739.3±60.0 °C at 760 mmHg
• 分子式: C₃₈H₇₅NO₄
• 熔点: N/A
• 闪点: 400.9±32.9 °C

用途

Hydroxy fatty acid (hFA)-sphingolipids help in formation and function of myelin. In addition, they also play a vital role in cell signaling, cell differentiation and apoptosis. In epidermis, hFA-ceramides aid in permeability barrier function. NAD(P)H-dependent enzyme, fatty acid 2-hydroxylase (FA2H) catalyzes the synthesis of hFA-ceramides. FA2H gene mutation leads to the development of neurological disorders such as leukodystrophy and spastic paraparesis in humans. hFA-ceramides help PM02734 (elisidepsin), an antitumor drug to exhibit its activity.

名称

• 中文名: N-(2'-(S)-羟基花生四烯基)-D-赤型鞘氨醇
• 英文名: (2S)-N-[(2S,3R,4E)-1,3-Dihydroxy-4-octadecen-2-yl]-2-hydroxyicosanamide

物理化学性质

• 密度: 0.9±0.1 g/cm3
• 沸点: 739.3±60.0 °C at 760 mmHg
• 分子式: C₃₈H₇₅NO₄
• 分子量: 610.006
• 闪点: 400.9±32.9 °C
• 精确质量: 609.569580
• LogP: 14.95
• 外观性状: 粉末
• 蒸汽压: 0.0±5.5 mmHg at 25°C
• 折射率: 1.486
• 储存条件: 20°C

英文别名

• Eicosanamide, 2-hydroxy-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-, (2S)-
• (2S)-N-[(2S,3R,4E)-1,3-Dihydroxy-4-octadecen-2-yl]-2-hydroxyicosanamide