Eletriptan-d3

• 常用名: Eletriptan-d3
• 英文名: Eletriptan-d3
• CAS号: 1287040-94-1
• 分子量: 385.54
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₃D₃N₂O₂S
• 熔点: N/A
• 闪点: N/A

Eletriptan-d3用途

Eletriptan-d3(Eletriptan-d3 HBr)是氘标记的氢溴酸Eletriptan。氢溴酸Eletriptan是一种选择性5-HT1B和5-HT1D受体激动剂,Ki分别为0.92 nM和3.14 nM[1][2]。

Eletriptan-d3名称

• 英文名: Eletriptan-d3

Eletriptan-d3生物活性

• 描述: Eletriptan-d3(Eletriptan-d3 HBr)是氘标记的氢溴酸Eletriptan。氢溴酸Eletriptan是一种选择性5-HT1B和5-HT1D受体激动剂,Ki分别为0.92 nM和3.14 nM[1][2]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Napier C, et al. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol, 1999, 368(2-3), 259-268.

  [3]. MaassenVanDenBrink A, et al. Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels. Neurology, 2000, 55(10), 1524-1530.

  [4]. Gupta P, et al. The in vivo pharmacological profile of eletriptan (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur J Pharmacol, 2000, 398(1), 73-81.

  [5]. Hoskin KL, et al. The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat. Brain Res, 2004, 998(1), 91-99.

Eletriptan-d3物理化学性质

• 分子式: C₂₂H₂₃D₃N₂O₂S
• 分子量: 385.54