MTDIA

• 常用名: MTDIA
• 英文名: MTDIA
• CAS号: 1399840-35-7
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: N/A
• 熔点: N/A
• 闪点: N/A

MTDIA用途

MTDIA, also known as MT-DADMe-ImmA, and Methylthio-DADMe-Immucillin A, is a MTAP inhibitor. Human 5'-methylthioadenosine phosphorylase (MTAP) is solely responsible for 5'-methylthioadenosine (MTA) metabolism to permit S-adenosylmethionine salvage. Transition-state (TS) analogues of MTAP are in development as anticancer candidates. TS analogues of MTAP incorporate a cationic nitrogen and a protonated 9-deazaadenine leaving group, which are mimics of the ribocation transition state. MT-ImmA and MT-DADMe-ImmA are two examples of these TS analogues.

MTDIA名称

• 英文名: MT-DADMe-ImmA

MTDIA物理化学性质

• InChIKey: XQKMBJFGNRIATG-UXQCFNEQSA-N
• SMILES: CSCC1C[NH+](Cc2c[nH]c3c(N)ncnc23)CC1O.[Cl-]

MTDIA靶点实验

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实验名称：Inhibition of Vibrio cholera N16961 MTAN -mediated adenine production by reverse-phas... 来源：ChEMBL 靶标：5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase External Id：CHEMBL1244610

实验名称：Antimicrobial activity against Vibrio cholerae N16961 assessed as effect on cell grow... 来源：ChEMBL 靶标：Vibrio cholerae External Id：CHEMBL1244609

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：Inhibition of MTAP in human CRL2522 cells by by ESI-MS analysis 来源：ChEMBL 靶标：S-methyl-5'-thioadenosine phosphorylase External Id：CHEMBL1244607

实验名称：Inhibition of MTAP in human FaDu cells by ESI-MS analysis 来源：ChEMBL 靶标：S-methyl-5'-thioadenosine phosphorylase External Id：CHEMBL1244606

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Inhibition of Escherichia coli O157:H7 EDL933 MTAN-mediated autoinducer-2 production ... 来源：ChEMBL 靶标：5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase External Id：CHEMBL1244617

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MTDIA英文别名

• MTDIA HCl