Collismycin A

• 常用名: Collismycin A
• 英文名: Collismycin A
• CAS号: 158792-24-6
• 分子量: 275.32600
• 密度: 1.27g/cm3
• 沸点: 381.2ºC at 760 mmHg
• 分子式: C₁₃H₁₃N₃O₂S
• 熔点: N/A
• 闪点: 184.3ºC

Collismycin A用途

Collismycin A is a bacterial metabolite with antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria and fungi. It inhibits proliferation of A549 lung, HCT116 colon, HeLa cervical cancer cells, and NIH373 fibroblasts but not MDA-MD-231 breast cancer cells. Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions. Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid.

Collismycin A名称

• 英文名: (2E)-4-methoxy-3-methylsulfanyl-2-(nitrosomethylidene)-6-pyridin-2-yl-1H-pyridine

Collismycin A物理化学性质

• 密度: 1.27g/cm3
• 沸点: 381.2ºC at 760 mmHg
• 分子式: C₁₃H₁₃N₃O₂S
• 分子量: 275.32600
• 闪点: 184.3ºC
• 精确质量: 275.07300
• PSA: 92.90000
• LogP: 2.68220
• 蒸汽压: 5.16E-06mmHg at 25°C
• 折射率: 1.624

Collismycin A安全信息

• 海关编码: 2933399090

Collismycin A海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Collismycin A靶点实验

查看更多实验

实验名称：USP8 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 8 External Id：USP8 FAST DUB HTS Primary

实验名称：USP17 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 17 like family member 5 External Id：USP17 FAST DUB HTS Primary

实验名称：USP7 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 7 External Id：USP7 FAST DUB HTS Primary

实验名称：Neuroprotective activity in 3 days postfertilized zebrafish larvae assessed as reduct... 来源：ChEMBL 靶标：Danio rerio External Id：CHEMBL2433983

实验名称：Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation a... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL1837406

实验名称：USP28 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 28 External Id：USP28 FAST DUB HTS Primary

实验名称：Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation 来源：ChEMBL 靶标：A549 External Id：CHEMBL1837399

实验名称：USP10 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 10 External Id：USP10 FAST DUB HTS Primary

实验名称：Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1837398

实验名称：UCHL1 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin C-terminal hydrolase L1 External Id：UCHL1 FAST DUB HTS Primary

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Collismycin A英文别名

• (E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehyde oxime
• (2,2'-Bipyridine)-6-carboxaldehyde,4-methoxy-5-(methylthio)-,oxime,(E)
• 4-methoxy-5-methylsulfanyl-[2,2']bipyridinyl-6-carbaldehyde oxime
• (E)-4-methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carboxaldehyde oxime
• Collismycin A