阿托伐他汀钙三水合物

更新时间：2024-01-04 22:58:53

阿托伐他汀钙三水合物结构式	常用名	阿托伐他汀钙三水合物	英文名	atorvastatin calcium trihydrate
	CAS号	344423-98-9	分子量	1209.388
	密度	N/A	沸点	N/A
	分子式	C₆₆H₇₄CaF₂N₄O₁₃	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS07, GHS08	信号词	Danger

阿托伐他汀钙三水合物用途

Atorvastatin is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin is also used for the treatment of dyslipidemia.

中文名	阿托伐他汀钙三水合物
英文名	atorvastatin calcium trihydrate
中文别名	阿托伐他汀钙水合物
英文别名	更多

分子式	C₆₆H₇₄CaF₂N₄O₁₃
分子量	1209.388
精确质量	1208.484619
PSA	256.93000
LogP	9.91090
外观性状	固体;White to Almost white powder to crystal
储存条件	室温，干燥
水溶解性	Very slightly soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

符号	GHS07, GHS08
信号词	Danger
危害声明	H319-H360D
警示性声明	P201-P280-P305 + P351 + P338-P308 + P313-P337 + P313
危害码 (欧洲)	T
风险声明 (欧洲)	61-36
安全声明 (欧洲)	53-26-45
危险品运输编码	NONH for all modes of transport

Statins demonstrate a broad anti-cytomegalovirus activity in vitro in ganciclovir-susceptible and resistant strains.

J. Med. Virol. 87(1) , 141-53, (2014)

Vasculoprotective and cholesterol-lowering properties are hallmarks of statins. Recently, statins have been found to exhibit antiviral activity. Little is known about the potential of statins against ...

Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.

Drug Metab. Pharmacokinet. 30(2) , 198-204, (2015)

Since drug-drug interaction (DDI) can affect organic anion-transporting polypeptide (OATP) and cause clinical events, prediction of such DDI is important in early clinical development. Although statin...

Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin.

Biol. Chem. 396(1) , 71-80, (2014)

Macrophages express several lysosomal cysteine proteases such as cathepsins and legumain. In this study, we assessed the expression, activity and secretion of legumain in cellular models of monocytes/...

atorvastatin calcium trihydrate

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1H-Pyrrole-1-heptanoicacid, 2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calcium salt, hydrate (2:1:3), (bR,dR)-

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