桑色素

更新时间：2024-01-03 11:58:06

桑色素结构式	常用名	桑色素	英文名	morin r. g.
	CAS号	654055-01-3	分子量	320.251
	密度	N/A	沸点	N/A
	分子式	C₁₅H₁₂O₈	熔点	299-300 °C (dec.)(lit.)
	MSDS	中文版美版	闪点	N/A
	符号	GHS07	信号词	Warning

桑色素用途

Morin is a yellow chemical compound that can be isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava). In a preclinical in vitro study, morin was found to be a weak inhibitor of fatty acid synthase with an IC50 of 2.33 μM. Morin was also found to inhibit amyloid formation by islet amyloid polypeptide (or amylin) and disaggregate amyloid fibers. Morin can be used to test for the presence of aluminium or tin in a solution, since it forms characteristically fluorescent coordination complexes with them.

中文名	桑色素
英文名	Morin hydrate
中文别名	桑色素 \| 桑色素/桑黄素 \| 3,5,7,2',4'五羥黃酮 \| 2',3,4',5,7-五羥黃酮 \| 桑色素/桑黄素水合物 \| 桑色素水合物 \| 桑黄素水合物 \| 摩林
英文别名	更多

熔点	299-300 °C (dec.)(lit.)
分子式	C₁₅H₁₂O₈
分子量	320.251
精确质量	320.053223
外观性状	yellow
储存条件	室温
水溶解性	methanol: soluble50mg/mL
分子结构	1、摩尔折射率：73.31 2、摩尔体积（cm³/mol）：167.9 3、等张比容（90.2K）：549.9 4、表面张力（dyne/cm）：114.8 5、极化率（10-24cm3）：29.06
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:6 3.氢键受体数量:8 4.可旋转化学键数量:1 5.互变异构体数量:366 6.拓扑分子极性表面积128 7.重原子数量:23 8.表面电荷:0 9.复杂度:488 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xi,T
风险声明 (欧洲)	36/37/38-25
安全声明 (欧洲)	26-36-45
危险品运输编码	UN 2811 6.1 / PGIII
RTECS号	LK8749000
包装等级	III

A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.

Sci. Transl. Med. 6(263) , 263ra161, (2014)

Lung cancer is the most common human malignancy and leads to about one-third of all cancer-related deaths. Lung adenocarcinomas harboring KRAS mutations, in contrast to those with EGFR and EML4-ALK mu...

Morin hydrate augments phagocytosis mechanism and inhibits LPS induced autophagic signaling in murine macrophage.

Int. Immunopharmacol. 22(2) , 356-65, (2014)

Morin, a natural flavonoid that is the primary bioactive constituent of the family Moraceae, has been found to be associated with many therapeutic properties. In this study, we evaluated the immunomod...

Drug screening boosted by hyperpolarized long-lived states in NMR.

ChemMedChem 9(11) , 2509-15, (2014)

Transverse and longitudinal relaxation times (T1ρ and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-live...

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