denatonium benzoate
denatonium benzoate structure
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Common Name | denatonium benzoate | ||
|---|---|---|---|---|
| CAS Number | 3734-33-6 | Molecular Weight | 446.581 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H34N2O3 | Melting Point | 164-168 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.
Curr. Biol. 24(17) , 1969-77, (2014) Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions.Here, we investigate the effects of acids on the taste neuron responses... |
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Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds.
Cancer Med. 4(2) , 245-52, (2015) Vismodegib, a highly selective inhibitor of hedgehog (Hh) pathway, is an approved treatment for basal-cell carcinoma. Patients on treatment with vismodegib often report profound alterations in taste sensation. The cellular mechanisms underlying the alteration... |
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A new dopaminergic nigro-olfactory projection.
Acta Neuropathol. 130 , 333-48, (2015) Parkinson disease (PD) is a neurodegenerative disorder characterized by massive loss of midbrain dopaminergic neurons. Whereas onset of motor impairments reflects a rather advanced stage of the disorder, hyposmia often marks the beginning of the disease. Litt... |
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Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking.
PLoS ONE 10 , e0127408, (2015) The STriatal-Enriched protein tyrosine Phosphatase (STEP) is a brain-specific phosphatase whose dysregulation in expression and/or activity is associated with several neuropsychiatric disorders. We recently showed that long-term excessive consumption of ethan... |
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Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction.
PLoS ONE 9(10) , e110373, (2014) Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved in r... |
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Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.
Proc. Natl. Acad. Sci. U. S. A. 111(22) , 8287-92, (2014) Chemosensory cells in the mucosal surface of the respiratory tract ("brush cells") use the canonical taste transduction cascade to detect potentially hazardous content and trigger local protective and aversive respiratory reflexes on stimulation. So far, the ... |
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Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways.
Diabetologia 57(10) , 2117-25, (2014) This study was designed to ascertain whether human enteroendocrine cells express bitter taste receptors, and whether activation of these receptors with bitter-tasting ligands induces secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).We used hu... |
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"A spoonful of sugar helps the medicine go down": bitter masking by sucrose among children and adults.
Chem. Senses 40(1) , 17-25, (2014) Sweeteners are often added to liquid formulations of drugs but whether they merely make them better tasting or actually reduce the perception of bitterness remains unknown. In a group of children and adults, we determined whether adding sucrose to urea, caffe... |
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The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.
J. Neurosci. 33(1) , 201-13, (2013) Bitter taste is a basic taste modality, required to safeguard animals against consuming toxic substances. Bitter compounds are recognized by G-protein-coupled bitter taste receptors (TAS2Rs). The human TAS2R10 responds to the toxic strychnine and numerous oth... |
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Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
J. Clin. Invest. 124(7) , 3263-73, (2014) The number of newly formed neurons declines rapidly during aging, and this decrease in neurogenesis is associated with decreased function of neural stem/progenitor cells (NPCs). Here, we determined that a WIP1-dependent pathway regulates NPC differentiation a... |