Somatotropin
Somatotropin structure
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Common Name | Somatotropin | ||
|---|---|---|---|---|
| CAS Number | 9002-72-6 | Molecular Weight | 154.120 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 410.7±35.0 °C at 760 mmHg | |
| Molecular Formula | C7H6O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 216.3±22.4 °C | |
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Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state.
J. Neurosci. 34(49) , 16309-19, (2014) The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth ho... |
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Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice.
Endocrinology 156(1) , 193-202, (2015) Peak bone mass, one of the most important predictors for fracture risk later in life, is attained during puberty and adolescence and influenced by neonatal and pubertal sex-specific gonadal hormones and GH-IGF-I secretion patterns. This study examined the eff... |
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Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131.
Life Sci. 109(1) , 20-9, (2014) The 28 amino acid hormone ghrelin, the natural ligand for the growth hormone secretagogue, or ghrelin receptor (GHR), has diverse physiological functions, including a possible role as a gastrointestinal prokinetic. The synthetic ghrelin mimetic RM-131 is in P... |
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GH administration patterns differently regulate epidermal growth factor signaling.
J. Endocrinol. 221(2) , 317-23, (2014) Current GH administration protocols imply frequent s.c. injections, resulting in suboptimal compliance. Therefore, there is interest in developing delivery systems for sustained release of the hormone. However, GH has different actions depending on its contin... |
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Supplement use by UK-based British Army soldiers in training.
Br. J. Nutr. 112(7) , 1175-84, (2014) The use of supplements is widespread at all levels of civilian sport and a prevalence of 60-90 % is reported among high-performance UK athletes, including juniors. The prevalence of supplement use among UK-based British Army personnel is not known. The aim of... |
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Novel cAMP binding protein-BP (CREBBP) mutation in a girl with Rubinstein-Taybi syndrome, GH deficiency, Arnold Chiari malformation and pituitary hypoplasia.
BMC Med. Genet. 14 , 28, (2013) Rubinstein-Taybi syndrome (RTS) is a rare autosomal dominant disorder (prevalence 1:125,000) characterised by broad thumbs and halluces, facial dysmorphism, psychomotor development delay, skeletal defects, abnormalities in the posterior fossa and short statur... |
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The combined effects of glutamine and growth hormone on intestinal anastomosis in the rat intra-abdominal sepsis model
J. Surg. Res. 182(1) , 142-5, (2013) Aim Intestinal anastomoses are always risky in patients who develop intra-abdominal sepsis. In this study, the effects of combined glutamine and growth hormone (GH) on healing of intestinal anastomosis following intestinal repair in the rat intra-abdominal se... |
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A mutant screening method by critical annealing temperature-PCR for site-directed mutagenesis.
BMC Biotechnol. 13 , 21, (2013) Distinguishing desired mutants from parental templates and undesired mutants is a problem not well solved in Quikchange™ mutagenesis. Although Dpn I digestion can eliminate methylated parental (WT) DNA, the efficiency is not satisfying due to the existence of... |
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Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2-/- mice.
J. Endocrinol. 223(1) , 93-106, (2014) The suppressor of cytokine signalling (Socs2(-/-))-knockout mouse is characterised by an overgrowth phenotype due to enhanced GH signalling. The objective of this study was to define the Socs2(-/-) bone phenotype and determine whether GH promotes bone mass vi... |
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Hypersomatotropism, acromegaly, and hyperadrenocorticism and feline diabetes mellitus.
Vet. Clin. North Am. Small Anim. Pract. 43(2) , 319-50, (2013) When confronted with a diabetic cat in clinical practice, it is tempting to assume it has a form of diabetes mellitus akin to human type 2 diabetes mellitus (diabetes). For most diabetic cats examined, this will indeed be justified. Nevertheless, a significan... |