Latest Articles of Biomacromolecules


3D Protein-Based Bilayer Artificial Skin for the Guided Scarless Healing of Third-Degree Burn Wounds in Vivo 10.1021/acs.biomac.7b01807 2018-04-18 Severe burn injuries can lead to delays in healing and devastating scar formation. Attempts have been made to develop a suitable skin substitute for the scarless healing of such skin wounds. Currently, there is no effective strategy for completely scarless he...
A Dual-Targeting Delivery System for Effective Genome Editing and In Situ Detecting Related Protein Expression in Edited Cells 10.1021/acs.biomac.8b00511 2018-04-16 One of critical steps in genome editing by CRISPR-Cas9 is to deliver the CRISPR-Cas9 system into targeted cells. In this study, we developed a dual-targeting delivery system based on polymer/inorganic hybrid nanoparticles to realize highly efficient genome ed...
Salt- and pH-Triggered Helix–Coil Transition of Ionic Polypeptides under Physiology Conditions 10.1021/acs.biomac.8b00204 2018-04-16 Controlling the helix–coil transition of polypeptides under physiological conditions is an attractive way toward smart functional materials. Here, we report the synthesis of a series of tertiary amine-functionalized ethylene glycol (EGx)-linked polypeptide el...
Allosteric Control of Peroxidase-Mimicking DNAzyme Activity with Cationic Copolymers 10.1021/acs.biomac.8b00201 2018-04-13 Control of protein conformation and function, induced by the binding of an effector, plays significant roles in modulating biochemical reaction. Although the DNAzymes catalytic activity is similar to protein-based enzymes, reports of allosterically controlled...
Photo- and Reduction-Responsive Polymersomes for Programmed Release of Small and Macromolecular Payloads 10.1021/acs.biomac.8b00253 2018-04-12 We report on the preparation of photo- and reduction-responsive diblock copolymers through reversible addition–fragmentation chain transfer (RAFT) polymerization of a coumarin-based disulfide-containing monomer (i.e., CSSMA) using a poly(ethylene oxide) (PEO)...
Sustainable Hydrogels Based on Lignin-Methacrylate Copolymers with Enhanced Water Retention and Tunable Material Properties 10.1021/acs.biomac.8b00282 2018-04-12 Synthesizing lignin-based copolymers would valorize a major coproduct stream from pulp and paper mills and biorefineries as well as reduce the dependence on petrochemical-based consumer goods. In this study, we used organosolv lignin isolated from hybrid popl...
One-Step Preparation of pH-Responsive Polymeric Nanogels as Intelligent Drug Delivery Systems for Tumor Therapy 10.1021/acs.biomac.8b00195 2018-04-11 In this work, pH-responsive polypeptide-based nanogels are reported as potential drug delivery systems. By the formation of pH-sensitive benzoic imine bonds, pH-responsive nanogels are constructed using hydrophilic methoxy poly(ethylene glycol)-b-poly[N-[N-(2...
Rational Design of Multifunctional Polymeric Nanoparticles Based on Poly(l-histidine) and d-α-Vitamin E Succinate for Reversing Tumor Multidrug Resistance 10.1021/acs.biomac.8b00213 2018-04-11 A multifunctional nanoparticulate system composed of methoxy poly(ethylene glycol)-poly(l-histidine)-d-α-vitamin E succinate (MPEG-PLH-VES) copolymers for encapsulation of doxorubicin (DOX) was elaborated with the aim of circumventing the multidrug resistance...
Processive Degradation of Crystalline Cellulose by a Multimodular Endoglucanase via a Wirewalking Mode 10.1021/acs.biomac.8b00340 2018-04-11 Processive hydrolysis of crystalline cellulose by cellulases is a critical step for lignocellulose deconstruction. The classic Trichoderma reesei exoglucanase TrCel7A, which has a closed active-site tunnel, starts each processive run by threading the tunnel w...
Liquid-State NMR Analysis of Nanocelluloses 10.1021/acs.biomac.8b00295 2018-04-11 Recent developments in ionic liquid electrolytes for cellulose or biomass dissolution has also allowed for high-resolution 1H and 13C NMR on very high molecular weight cellulose. This permits the development of advanced liquid-state quantitative NMR methods f...

3D Protein-Based Bilayer Artificial Skin for the Guided Scarless Healing of Third-Degree Burn Wounds in Vivo

10.1021/acs.biomac.7b01807

2018-04-18

Severe burn injuries can lead to delays in healing and devastating scar formation. Attempts have been made to develop a suitable skin substitute for the scarless healing of such skin wounds. Currently, there is no effective strategy for completely scarless he...

A Dual-Targeting Delivery System for Effective Genome Editing and In Situ Detecting Related Protein Expression in Edited Cells

10.1021/acs.biomac.8b00511

2018-04-16

One of critical steps in genome editing by CRISPR-Cas9 is to deliver the CRISPR-Cas9 system into targeted cells. In this study, we developed a dual-targeting delivery system based on polymer/inorganic hybrid nanoparticles to realize highly efficient genome ed...

Salt- and pH-Triggered Helix–Coil Transition of Ionic Polypeptides under Physiology Conditions

10.1021/acs.biomac.8b00204

2018-04-16

Controlling the helix–coil transition of polypeptides under physiological conditions is an attractive way toward smart functional materials. Here, we report the synthesis of a series of tertiary amine-functionalized ethylene glycol (EGx)-linked polypeptide el...

Allosteric Control of Peroxidase-Mimicking DNAzyme Activity with Cationic Copolymers

10.1021/acs.biomac.8b00201

2018-04-13

Control of protein conformation and function, induced by the binding of an effector, plays significant roles in modulating biochemical reaction. Although the DNAzymes catalytic activity is similar to protein-based enzymes, reports of allosterically controlled...

Photo- and Reduction-Responsive Polymersomes for Programmed Release of Small and Macromolecular Payloads

10.1021/acs.biomac.8b00253

2018-04-12

We report on the preparation of photo- and reduction-responsive diblock copolymers through reversible addition–fragmentation chain transfer (RAFT) polymerization of a coumarin-based disulfide-containing monomer (i.e., CSSMA) using a poly(ethylene oxide) (PEO)...

Sustainable Hydrogels Based on Lignin-Methacrylate Copolymers with Enhanced Water Retention and Tunable Material Properties

10.1021/acs.biomac.8b00282

2018-04-12

Synthesizing lignin-based copolymers would valorize a major coproduct stream from pulp and paper mills and biorefineries as well as reduce the dependence on petrochemical-based consumer goods. In this study, we used organosolv lignin isolated from hybrid popl...

One-Step Preparation of pH-Responsive Polymeric Nanogels as Intelligent Drug Delivery Systems for Tumor Therapy

10.1021/acs.biomac.8b00195

2018-04-11

In this work, pH-responsive polypeptide-based nanogels are reported as potential drug delivery systems. By the formation of pH-sensitive benzoic imine bonds, pH-responsive nanogels are constructed using hydrophilic methoxy poly(ethylene glycol)-b-poly[N-[N-(2...

Rational Design of Multifunctional Polymeric Nanoparticles Based on Poly(l-histidine) and d-α-Vitamin E Succinate for Reversing Tumor Multidrug Resistance

10.1021/acs.biomac.8b00213

2018-04-11

A multifunctional nanoparticulate system composed of methoxy poly(ethylene glycol)-poly(l-histidine)-d-α-vitamin E succinate (MPEG-PLH-VES) copolymers for encapsulation of doxorubicin (DOX) was elaborated with the aim of circumventing the multidrug resistance...

Processive Degradation of Crystalline Cellulose by a Multimodular Endoglucanase via a Wirewalking Mode

10.1021/acs.biomac.8b00340

2018-04-11

Processive hydrolysis of crystalline cellulose by cellulases is a critical step for lignocellulose deconstruction. The classic Trichoderma reesei exoglucanase TrCel7A, which has a closed active-site tunnel, starts each processive run by threading the tunnel w...

Liquid-State NMR Analysis of Nanocelluloses

10.1021/acs.biomac.8b00295

2018-04-11

Recent developments in ionic liquid electrolytes for cellulose or biomass dissolution has also allowed for high-resolution 1H and 13C NMR on very high molecular weight cellulose. This permits the development of advanced liquid-state quantitative NMR methods f...