10.1016/j.cell.2017.06.047

2017-07-13

Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering...

10.1016/j.cell.2017.06.046

2017-07-13

Dupilumab is a fully human IgG4 monoclonal antibody directed against the IL-4Rα subunit of IL-4 and IL-13 receptors. It blocks the signaling pathways of IL-4 and IL-13, key cytokines that drive type 2 inflammatory response. In March 2017, dupilumab was approv...

10.1016/j.cell.2017.06.044

2017-07-13

(Cell 157, 313–328; April 10, 2014)

10.1016/j.cell.2017.06.043

2017-07-13

To study how genes, cells, or organisms operate in natural environments, researchers often need to leave the bench and venture into the field. Here are a few approaches that field biologists use in designing and conducting semi-wild experiments and the many c...

10.1016/j.cell.2017.06.040

2017-07-13

The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with multiple viral vaccine platforms has been established in animals, no study has addressed protection dur...

10.1016/j.cell.2017.06.038

2017-07-13

The yeast Hsp70 chaperone Ssb interacts with ribosomes and nascent polypeptides to assist protein folding. To reveal its working principle, we determined the nascent chain-binding pattern of Ssb at near-residue resolution by in vivo selective ribosome profili...

10.1016/j.cell.2017.06.037

2017-07-13

Alternative splicing (AS) patterns have diverged rapidly during vertebrate evolution, yet the functions of most species- and lineage-specific splicing events are not known. We observe that mammalian-specific AS events are enriched in transcript sequences enco...

10.1016/j.cell.2017.06.036

2017-07-13

The nervous system—in particular, the brain and its cognitive abilities—is among humans’ most distinctive and impressive attributes. How the nervous system has changed in the human lineage and how it differs from that of closely related primates is not well u...

10.1016/j.cell.2017.06.035

2017-07-13

Injured skeletal muscle regenerates, but with age or in muscular dystrophies, muscle is replaced by fat. Upon injury, muscle-resident fibro/adipogenic progenitors (FAPs) proliferated and gave rise to adipocytes. These FAPs dynamically produced primary cilia, ...

10.1016/j.cell.2017.06.033

2017-07-13

The most abundant biological entities on Earth still have a few tricks up their sleeve, and a recent surge of research is reinvigorating the field. With the potential to dramatically expand known protein sequence space, give insights into unprecedented biolog...