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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells
10.1016/j.stem.2017.06.004 2017-07-13 Glioblastomas exhibit a hierarchical cellular organization, suggesting that they are driven by neoplastic stem cells that retain partial yet abnormal differentiation potential. Here, we show that a large subset of patient-derived glioblastoma stem cells (GSCs... |
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Lineage Tracing: Papers and Progress
10.1016/j.stem.2017.06.015 2017-07-06 This i3 is a data visualization based on theCell Stem Celltenth anniversary theme of lineage tracing. Using Scopus citations ofCell Stem Cellresearch papers, it illustrates both the evolution of the stem cell field and the way new research builds on work that... |
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Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity
10.1016/j.stem.2017.06.014 2017-07-06 Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we explored inter-relationships between putative mouse ISC populations by comparative RNA-sequencing (RNA-seq)... |
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Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success
10.1016/j.stem.2017.06.011 2017-07-06 The ability to directly reprogram mature cells to alternative fates challenges concepts of how cell identities are maintained, erased, and acquired. Recent advances in understanding and overcoming hurdles to direct neuronal conversion have provided new insigh... |
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Making HSCs on Demand: Looking Ahead
10.1016/j.stem.2017.06.010 2017-07-06 George Daley and Shahin Rafii’s groups recently generated multilineage, serially engrafting hematopoietic stem cells (HSCs) from human pluripotent stem cells and endothelial cells, respectively, achieving an important research milestone for the field. We aske... |
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Stem Cells: All that Is Solid Melts into Air
10.1016/j.stem.2017.06.009 2017-07-06 The intestinal epithelium displays great resilience, as several cell populations can replenish the stem cell pool upon damage. Two studies inCell Stem Cellextend this capacity to enteroendocrine cells, addressing the molecular basis underlying cellular plasti... |
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Modeling the Glomerular Filtration Barrier: Are You Kidney-ing Me?
10.1016/j.stem.2017.06.008 2017-07-06 Podocyte depletion drives kidney disease and kidney failure progression, but podocyte complexity at the glomerular filtration barrier is difficult to model in vitro. InNature Biomedical Engineering, Musah et al. (2017) developed a multifluidic device with iPS... |
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Generation of Human Hair Cells In Vitro: Is It All about How the Wnt Blows?
10.1016/j.stem.2017.06.007 2017-07-06 Screening for small molecules or drugs that can protect or restore mechanosensory hair cells has been hampered by limited cell numbers. InNature Biotechnology, Koehler et al. (2017) have developed a human organoid-based approach using basic developmental prin... |
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The aCCR(2)ual of M2 Macrophages Provides Some Breathing Room
10.1016/j.stem.2017.06.006 2017-07-06 Lung tissue can robustly regenerate functional alveolar units after injury, but the mechanisms are unknown. Lechner et al. (2017) in this issue ofCell Stem Celldemonstrate that lung regeneration is facilitated by bone-marrow-derived myeloid cells that are rec... |
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The Evolving Roles of Human iPSC-Derived Cardiomyocytes in Drug Safety and Discovery
10.1016/j.stem.2017.06.005 2017-07-06 Nonclinical studies of drug effects with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide new possibilities for evaluating drug safety and efficacy. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm provides lessons ... |