Latest Articles of Biomaterials


pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time 10.1016/j.biomaterials.2018.04.002 2018-04-04 Nanoparticle-based tumor therapies are extensively studied; however, few are capable of improving patient survival time due to premature drug leakage, off target effects, and poor tissue penetration. Previously, we successfully synthesized a novel family of Y...
PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model 10.1016/j.biomaterials.2018.04.004 2018-04-04 Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic...
3D printing of a lithium-calcium-silicate crystal bioscaffold with dual bioactivities for osteochondral interface reconstruction 10.1016/j.biomaterials.2018.04.005 2018-04-04 It is difficult to achieve self-healing outcoming for the osteochondral defects caused by degenerative diseases. The simultaneous regeneration of both cartilage and subchondral bone tissues is an effective therapeutic strategy for osteochondral defects. Howev...
Photopolymerized dynamic hydrogels with tunable viscoelastic properties through thioester exchange 10.1016/j.biomaterials.2018.03.060 2018-04-04 The extracellular matrix (ECM) constitutes a viscoelastic environment for cells. A growing body of evidence suggests that the behavior of cells cultured in naturally-derived or synthetic ECM mimics is influenced by the viscoelastic properties of these substra...
Second near-infrared emissive lanthanide complex for fast renal-clearable in vivo optical bioimaging and tiny tumor detection 10.1016/j.biomaterials.2018.03.041 2018-04-03 In vivo optical imaging by using a new imaging window located at short-wavelength infrared region (1000–1700 nm, named as NIR II) presents an unprecedented improvement in imaging sensitivity and spatial resolution over the traditional visible and near-infrare...
Combination cancer treatment through photothermally controlled release of selenous acid from gold nanocages 10.1016/j.biomaterials.2018.03.058 2018-04-03 Selenite, one of the inorganic forms of selenium, is emerging as an attractive chemotherapeutic agent owing to its selectivity in eradicating cancer cells. Here we demonstrate a new formulation of nanomedicine based on selenous acid, which is mixed with lauri...
Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles 10.1016/j.biomaterials.2018.04.003 2018-04-03 Encouraging results are emerging from systems that exploit Toll like receptor (TLR) signaling, nanotechnology, checkpoint inhibition and molecular imaging for cancer immunotherapy. A major remaining challenge is developing effective, durable and tumour-specif...
The critical chemical and mechanical regulation of folic acid on neural engineering 10.1016/j.biomaterials.2018.03.059 2018-04-03 The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of acti...
Src activation decouples cell division orientation from cell geometry in mammalian cells 10.1016/j.biomaterials.2018.03.052 2018-04-03 Orientation of cell division plane plays a crucial role in morphogenesis and regeneration. Misoriented cell division underlies many important diseases, such as cancer. Studies with Drosophila and C. elegance models show that Src, a proto-oncogene tyrosine-pro...
Ultra-thin, aligned, free-standing nanofiber membranes to recapitulate multi-layered blood vessel/tissue interface for leukocyte infiltration study 10.1016/j.biomaterials.2018.03.053 2018-03-31 Leukocyte infiltration plays critical roles in tissue inflammation for pathogen clearance and tumor eradication. This process is regulated by complex microenvironments in blood vessels, including inflamed endothelium, blood flow, and perivascular components. ...

pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time

10.1016/j.biomaterials.2018.04.002

2018-04-04

Nanoparticle-based tumor therapies are extensively studied; however, few are capable of improving patient survival time due to premature drug leakage, off target effects, and poor tissue penetration. Previously, we successfully synthesized a novel family of Y...

PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model

10.1016/j.biomaterials.2018.04.004

2018-04-04

Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic...

3D printing of a lithium-calcium-silicate crystal bioscaffold with dual bioactivities for osteochondral interface reconstruction

10.1016/j.biomaterials.2018.04.005

2018-04-04

It is difficult to achieve self-healing outcoming for the osteochondral defects caused by degenerative diseases. The simultaneous regeneration of both cartilage and subchondral bone tissues is an effective therapeutic strategy for osteochondral defects. Howev...

Photopolymerized dynamic hydrogels with tunable viscoelastic properties through thioester exchange

10.1016/j.biomaterials.2018.03.060

2018-04-04

The extracellular matrix (ECM) constitutes a viscoelastic environment for cells. A growing body of evidence suggests that the behavior of cells cultured in naturally-derived or synthetic ECM mimics is influenced by the viscoelastic properties of these substra...

Second near-infrared emissive lanthanide complex for fast renal-clearable in vivo optical bioimaging and tiny tumor detection

10.1016/j.biomaterials.2018.03.041

2018-04-03

In vivo optical imaging by using a new imaging window located at short-wavelength infrared region (1000–1700 nm, named as NIR II) presents an unprecedented improvement in imaging sensitivity and spatial resolution over the traditional visible and near-infrare...

Combination cancer treatment through photothermally controlled release of selenous acid from gold nanocages

10.1016/j.biomaterials.2018.03.058

2018-04-03

Selenite, one of the inorganic forms of selenium, is emerging as an attractive chemotherapeutic agent owing to its selectivity in eradicating cancer cells. Here we demonstrate a new formulation of nanomedicine based on selenous acid, which is mixed with lauri...

Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles

10.1016/j.biomaterials.2018.04.003

2018-04-03

Encouraging results are emerging from systems that exploit Toll like receptor (TLR) signaling, nanotechnology, checkpoint inhibition and molecular imaging for cancer immunotherapy. A major remaining challenge is developing effective, durable and tumour-specif...

The critical chemical and mechanical regulation of folic acid on neural engineering

10.1016/j.biomaterials.2018.03.059

2018-04-03

The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of acti...

Src activation decouples cell division orientation from cell geometry in mammalian cells

10.1016/j.biomaterials.2018.03.052

2018-04-03

Orientation of cell division plane plays a crucial role in morphogenesis and regeneration. Misoriented cell division underlies many important diseases, such as cancer. Studies with Drosophila and C. elegance models show that Src, a proto-oncogene tyrosine-pro...

Ultra-thin, aligned, free-standing nanofiber membranes to recapitulate multi-layered blood vessel/tissue interface for leukocyte infiltration study

10.1016/j.biomaterials.2018.03.053

2018-03-31

Leukocyte infiltration plays critical roles in tissue inflammation for pathogen clearance and tumor eradication. This process is regulated by complex microenvironments in blood vessels, including inflamed endothelium, blood flow, and perivascular components. ...