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Reclassification of Nocardia species based on whole genome sequence and associated phenotypic data
10.1038/s41429-018-0043-1 2018-04-04 Type strains of 72 validated Nocardia species were phylogenetically analyzed based on the multilocus sequence analysis (MLSA) concatenated atpD–groL1–groL2–recA–rpoA–secY–sodA–ychF. Furthermore, their similarity based on digital DNA–DNA hybridization (dDDH) w... |
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Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475
10.1038/s41429-018-0046-y 2018-04-04 Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2−5) roquefortine alkaloids, along with six ergosterol analogues (6−11). The planar ... |
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Correction to: Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria
10.1038/s41429-017-0019-6 2018-03-27 Correction to: Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria Correction to: Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halicho... |
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Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981
10.1038/s41429-018-0041-3 2018-03-22 A new dipeptide, named tolyprolinol, was isolated from the static culture of a fungus, Tolypocladium sp. FKI-7981. The structure of tolyprolinol was elucidated as N-acetyl-l-phenylalanyl-l-prolinol. It showed moderate antimalarial activity but did not show cy... |
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Cystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp.
10.1038/s41429-018-0044-0 2018-03-22 We identified a new cyclic lipodepsipeptide, cystargamide B (1), from the mycelial extract of a Kaempferia galanga rhizome-derived actinomycete strain, Streptomyces sp. PB013. The planar structure was elucidated based on high resolution fast-atom bombardment ... |
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Confirmation of the absolute configuration of Stachybotrin C using single-crystal X-ray diffraction analysis of its 4-bromobenzyl ether derivative
10.1038/s41429-018-0042-2 2018-03-19 The absolute configuration of Stachybotrin C was confirmed in this study. After synthesizing the dimethyl ethers of Stachybotrin C, the C-8 epimer was analyzed by 1D NOESY. However, the stereochemistry determination was difficult through the NOE correlations.... |
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Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium
10.1038/s41429-018-0040-4 2018-03-14 New polycyclic tetramate macrolactams, Umezawamides A (1) and B (2) were isolated from a combined-culture of Umezawaea sp. RD066910 and mycolic-acid containing bacterium Tsukamurella pulmonis TP-B0596. Their planar structures and partial stereochemistries wer... |
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Spiciferone analogs from an endophytic fungus Phoma betae collected from desert plants in West China
10.1038/s41429-018-0037-z 2018-03-14 Endophytic fungi from desert, arid, and grassland areas are an ecologically important but unique group with poor chemical investigation. During our ongoing study to mine bioactive secondary metabolites from unique fungal environments, a new shunt product spic... |
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Streptosporangium minutum sp. nov., isolated from garden soil exposed to microwave radiation
10.1038/s41429-018-0036-0 2018-03-07 The actinobacterium, strain M26T, was isolated from garden soil that was pre-treated with microwave radiation. The soil sample was collected in Roodepoort, Gauteng Province, South Africa as part of an antibiotic-screening programme. The isolate produced branc... |
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Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454
10.1038/s41429-018-0039-x 2018-03-07 Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data... |