Latest Articles of Chemistry and Physics of Lipids


Direct carborane-peptide conjugates: Synthesis and evaluation as non-natural lipopeptide mimetics 10.1016/j.chemphyslip.2018.03.009 2018-03-29 Herein, we report the synthesis and characterization of direct carborane-peptide conjugates. Carboranes are non-natural and extremely hydrophobic compounds and turned out to be suitable pharmacophores for diverse biological applications. In this work, we esta...
Molecular interactions of active constituents of essential oils in zwitterionic lipid bilayers 10.1016/j.chemphyslip.2018.03.008 2018-03-27 Eugenol and its related compounds are major active constituents of essential oils and have been extensively used as food flavoring agents with significant lipid peroxidation inhibition activity, highlighting the importance of understanding detailed molecular ...
Implications of the Mediterranean diet and physical exercise on the lipid profile of metabolically healthy obese women as measured by nuclear magnetic resonance spectroscopy (1H NMR) 10.1016/j.chemphyslip.2018.03.007 2018-03-23 Objective There is a lack of consensus when it comes to establishing the biochemical parameters that define metabolically healthy obese (MHO) subjects. Indeed, most studies do not include subjects’ lipid profiles. Our objective was to characterize lipoprotein...
Niemann-Pick C2 protein regulates sterol transport between plasma membrane and late endosomes in human fibroblasts 10.1016/j.chemphyslip.2018.03.006 2018-03-23 Niemann-Pick disease type C2 is a lipid storage disorder in which mutations in the NPC2 protein cause accumulation of lipoprotein-derived cholesterol in late endosomes and lysosomes (LE/LYSs). Whether cholesterol delivered by other means to NPC2 deficient cel...
Surface modification of paclitaxel-loaded liposomes using d-α-tocopheryl polyethylene glycol 1000 succinate: Enhanced cellular uptake and cytotoxicity in multidrug resistant breast cancer cells 10.1016/j.chemphyslip.2018.03.005 2018-03-14 Liposomes can achieve a controlled release and an improved bioavailability of water- insoluble drug with minimized side effects. Paclitaxel is an efficient anticancer drug for the treatment of various cancers. However, paclitaxel has a solubility of 0.5 mg/L ...
Macrophage Sphingolipids are Essential for the Entry of Mycobacteria 10.1016/j.chemphyslip.2018.03.004 2018-03-08 Mycobacteria are intracellular pathogens that can invade and survive within host macrophages. Mycobacterial infections remain a major cause of mortality and morbidity worldwide, with serious concerns of emergence of multi and extensively drug-resistant tuberc...
Headgroup hydroxylation by OlsE occurs at the C4 position of ornithine lipid and is widespread in proteobacteria and bacteroidetes 10.1016/j.chemphyslip.2018.03.002 2018-03-07 Amino acid-containing acyloxyacyl lipids are composed of a 3-hydroxy fatty acid amide-bound to the α-amino group of an amino acid. A second fatty acid is ester-linked to the 3-hydroxy group of the first fatty acid. Most commonly, ornithine is the headgroup of...
Antioxidants inhibit low density lipoprotein oxidation less at lysosomal pH: A possible explanation as to why the clinical trials of antioxidants might have failed 10.1016/j.chemphyslip.2018.03.001 2018-03-05 Oxidised low density lipoprotein (LDL) was considered to be important in the pathogenesis of atherosclerosis, but the large clinical trials of antioxidants, including the first one using probucol (the PQRST Trial), failed to show benefit and have cast doubt o...
DPPC Monolayer response to Non-Spanning Cobalt-cage Metallosurfactants: Electrostatic Complex Formation 10.1016/j.chemphyslip.2018.02.003 2018-02-27 A novel series of amphiphilic cobalt-cage derivatives (ACCD), bearing a diaza-crown bridge and varying alkyl chains, facilitate ion transport across biomembrane models via self-aggregation. In this study, compression isotherm analyses and atomic force microsc...
Continuous Detection of Entry of Cell-Penetrating Peptide Transportan 10 into Single Vesicles 10.1016/j.chemphyslip.2018.02.001 2018-02-06 Entry of cell-penetrating peptides (CPPs) into living cells by translocating across plasma membranes is an important physiological phenomenon. To elucidate the mechanism of the translocation of CPPs across lipid bilayers, it is essential to reveal its element...

Direct carborane-peptide conjugates: Synthesis and evaluation as non-natural lipopeptide mimetics

10.1016/j.chemphyslip.2018.03.009

2018-03-29

Herein, we report the synthesis and characterization of direct carborane-peptide conjugates. Carboranes are non-natural and extremely hydrophobic compounds and turned out to be suitable pharmacophores for diverse biological applications. In this work, we esta...

Molecular interactions of active constituents of essential oils in zwitterionic lipid bilayers

10.1016/j.chemphyslip.2018.03.008

2018-03-27

Eugenol and its related compounds are major active constituents of essential oils and have been extensively used as food flavoring agents with significant lipid peroxidation inhibition activity, highlighting the importance of understanding detailed molecular ...

Implications of the Mediterranean diet and physical exercise on the lipid profile of metabolically healthy obese women as measured by nuclear magnetic resonance spectroscopy (1H NMR)

10.1016/j.chemphyslip.2018.03.007

2018-03-23

Objective There is a lack of consensus when it comes to establishing the biochemical parameters that define metabolically healthy obese (MHO) subjects. Indeed, most studies do not include subjects’ lipid profiles. Our objective was to characterize lipoprotein...

Niemann-Pick C2 protein regulates sterol transport between plasma membrane and late endosomes in human fibroblasts

10.1016/j.chemphyslip.2018.03.006

2018-03-23

Niemann-Pick disease type C2 is a lipid storage disorder in which mutations in the NPC2 protein cause accumulation of lipoprotein-derived cholesterol in late endosomes and lysosomes (LE/LYSs). Whether cholesterol delivered by other means to NPC2 deficient cel...

Surface modification of paclitaxel-loaded liposomes using d-α-tocopheryl polyethylene glycol 1000 succinate: Enhanced cellular uptake and cytotoxicity in multidrug resistant breast cancer cells

10.1016/j.chemphyslip.2018.03.005

2018-03-14

Liposomes can achieve a controlled release and an improved bioavailability of water- insoluble drug with minimized side effects. Paclitaxel is an efficient anticancer drug for the treatment of various cancers. However, paclitaxel has a solubility of 0.5 mg/L ...

Macrophage Sphingolipids are Essential for the Entry of Mycobacteria

10.1016/j.chemphyslip.2018.03.004

2018-03-08

Mycobacteria are intracellular pathogens that can invade and survive within host macrophages. Mycobacterial infections remain a major cause of mortality and morbidity worldwide, with serious concerns of emergence of multi and extensively drug-resistant tuberc...

Headgroup hydroxylation by OlsE occurs at the C4 position of ornithine lipid and is widespread in proteobacteria and bacteroidetes

10.1016/j.chemphyslip.2018.03.002

2018-03-07

Amino acid-containing acyloxyacyl lipids are composed of a 3-hydroxy fatty acid amide-bound to the α-amino group of an amino acid. A second fatty acid is ester-linked to the 3-hydroxy group of the first fatty acid. Most commonly, ornithine is the headgroup of...

Antioxidants inhibit low density lipoprotein oxidation less at lysosomal pH: A possible explanation as to why the clinical trials of antioxidants might have failed

10.1016/j.chemphyslip.2018.03.001

2018-03-05

Oxidised low density lipoprotein (LDL) was considered to be important in the pathogenesis of atherosclerosis, but the large clinical trials of antioxidants, including the first one using probucol (the PQRST Trial), failed to show benefit and have cast doubt o...

DPPC Monolayer response to Non-Spanning Cobalt-cage Metallosurfactants: Electrostatic Complex Formation

10.1016/j.chemphyslip.2018.02.003

2018-02-27

A novel series of amphiphilic cobalt-cage derivatives (ACCD), bearing a diaza-crown bridge and varying alkyl chains, facilitate ion transport across biomembrane models via self-aggregation. In this study, compression isotherm analyses and atomic force microsc...

Continuous Detection of Entry of Cell-Penetrating Peptide Transportan 10 into Single Vesicles

10.1016/j.chemphyslip.2018.02.001

2018-02-06

Entry of cell-penetrating peptides (CPPs) into living cells by translocating across plasma membranes is an important physiological phenomenon. To elucidate the mechanism of the translocation of CPPs across lipid bilayers, it is essential to reveal its element...