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Diversification of 6‐bromo‐2‐substituted Pyridine Derivatives via Suzuki‐Miyaura Cross‐Coupling
10.1002/jhet.3144 2018-04-06 The functionalized pyridine ring is a ubiquitous moiety in numerous research areas including materials, natural products, as well as agrochemicals and is a strategic synthon for heteroaromatic synthetic method development. Pyridinyl ligand scaffolds are also ... |
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Design and Synthesis of Imidazo[1,2‐a]pyridines with Carboxamide Group Substitution and In silico Evaluation of their Interaction with a LuxR‐type Quorum Sensing Receptor
10.1002/jhet.3140 2018-03-25 Quorum sensing, an important process of bacterial communication, is involved in the development of complex behavior and expression of virulence factors that become important due to its key role in infection process. In this manuscript, docking studies were us... |
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Synthesis and Biological Evaluation of New Multifunctional Oxazolone Scaffolds Incorporating Phenyl Benzoate Moiety
10.1002/jhet.3139 2018-03-25 Oxazolone derivative 3a was utilized as a versatile precursor for the construction of new heterocyclic scaffolds containing imidazole, oxazine, triazine, and triazole rings (compounds 20, 21, 23, and 24, respectively). Furthermore, 4‐aminohippuric acid (2b) w... |
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Design, Preparation of 3‐Hydroxy Isoindolinone Cyclotripeptides, and the In Vitro Antitumor Activities Against Cervical Carcinoma HeLa Cells
10.1002/jhet.3154 2018-03-23 Photoinduced single electron transfer cyclization processes for synthesis of a series of 3‐hydroxy isoindolinone cyclotripeptides containing double pharmacophores (cyclotripeptides and phthalimide moiety) are described to develop novel antitumor cyclopeptide ... |
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Isolation of 5‐Hydroxy‐γ‐lactams from a Classical 2‐Aminopyrrole Synthesis
10.1002/jhet.3156 2018-03-22 5‐hydroxy‐γ‐lactams have been isolated as major byproducts from a classical 2‐aminopyrrole synthesis involving condensation of an in situ prepared α‐aminoketone with methyl cyanoacetate. The classical 2‐aminopyrrole was obtained in very low yield, or not at a... |
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Stereocomplementary Synthesis of cis‐ and trans‐2‐(p‐Bromophenyl)‐5‐methylthiazolidin‐4‐ones: Useful Umpolung‐type Suzuki–Miyaura Cross‐coupling Partner and Donor
10.1002/jhet.3141 2018-03-14 Novel cis‐ and trans‐2‐(p‐bromophenyl)‐5‐methylthiazolidin‐4‐ones, S,N‐containing heterocyclic compounds, were provided in a cis‐stereocomplementary and trans‐stereocomplementary synthetic manner. cis‐Selective cyclo‐condensation proceeded between 2‐sulfanylp... |
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Structural Elucidation and Antimicrobial Evaluation of Novel [1,2,4]Triazolo[4,3‐a]pyrimidines and Pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones
10.1002/jhet.3146 2018-03-14 1,3‐Di(thiophen‐2‐yl)prop‐2‐en‐1‐one (1) was utilized in the synthesis of 4,6‐di(thiophen‐2‐yl)‐3,4‐dihydropyrimidine‐2(1H)‐thione (2) and 5,7‐di(thiophen‐2‐yl)‐2‐thioxo‐2,3‐dihydropyrido[2,3‐d]pyrimidin‐4(1H)‐one (4). The latter thiones were used in the synt... |
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Synthesis, Characterization, Antimicrobial Screening, and Computational Studies of a Tripodal Schiff Base Containing Pyrimidine Unit
10.1002/jhet.3142 2018-03-14 A novel tripodal Schiff base ligand, 5‐amino‐2,4,6‐tris(4‐carboxybenzimino)‐1,3‐pyrimidine (TTPS), was synthesized for the first time by the reaction of 2,4,5,6‐tetraaminopyrimidine with 4‐carboxybenzaldehyde. The ligand was characterized by means of ultravio... |
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Issue Information
10.1002/jhet.2998 2018-03-14 No abstract is available for this article. |
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An Aurone‐derived Low‐molecular‐weight Fluorescence Probe for the Detection of Hg2+ in Aqueous Solution and Living Cells
10.1002/jhet.3143 2018-03-13 A low‐molecular‐weight fluorescent probe 1 (M.W. = 238.24) based on aurone was synthesized, and its application in fluorescent detection of Hg2+ in aqueous solution and living cells was reported. It exhibited an “on–off” fluorescent response toward Hg2+ in aq... |