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Nanoscopic Resolution of the Glass Transition within Spatially Inhomogeneous Polymer Mixtures
10.1021/acscentsci.8b00164 2018-04-06 Christie, Register, and Priestley report the first direct measurement of the glass transition temperature as a function of location within a bulk nanostructured polymer material. |
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Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery
10.1021/acscentsci.8b00098 2018-04-05 Cell-penetrating peptides (CPPs) can facilitate the intracellular delivery of large therapeutically relevant molecules, including proteins and oligonucleotides. Although hundreds of CPP sequences are described in the literature, predicting efficacious sequenc... |
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Elegant Approach to the Controllability of the Mechanical Properties of a Microgel via the Self-Assembly of Internal Molecules
10.1021/acscentsci.8b00167 2018-04-05 Gelatin microgels synthesized inside droplets and stabilized by lipid membranes could move the field of protein-like polymer microgels. |
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Mapping Catalytically Relevant Edge Electronic States of MoS2
10.1021/acscentsci.8b00042 2018-04-03 Molybdenum disulfide (MoS2) is a semiconducting transition metal dichalcogenide that is known to be a catalyst for both the hydrogen evolution reaction (HER) as well as for hydro-desulfurization (HDS) of sulfur-rich hydrocarbon fuels. Specifically, the edges ... |
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Detecting the Sweet Biomarker on Cancer Cells
10.1021/acscentsci.8b00156 2018-03-29 A sugar molecule expressed on cancer cells can be chemoenzymatically labeled for fluorescent imaging and proteomic analysis. |
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Development and Application of Yeast and Phage Display of Diverse Lanthipeptides
10.1021/acscentsci.7b00581 2018-03-28 Peptide display has enabled identification and optimization of ligands to many targets. These ligands are usually linear or disulfide-containing peptides that are vulnerable to proteolysis or reduction. We report yeast surface and phage display of lanthipepti... |
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Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics
10.1021/acscentsci.7b00612 2018-03-28 The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin sequences revealed the presence of conserved tyrosine resid... |
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Extra-Large Pore Mesoporous Silica Nanoparticles Enabling Co-Delivery of High Amounts of Protein Antigen and Toll-like Receptor 9 Agonist for Enhanced Cancer Vaccine Efficacy
10.1021/acscentsci.8b00035 2018-03-28 Cancer vaccine aims to invoke antitumor adaptive immune responses to detect and eliminate tumors. However, the current dendritic cells (DCs)-based cancer vaccines have several limitations that are mostly derived from the ex vivo culture of patient DCs. To cir... |
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Stable Metal–Organic Frameworks with Group 4 Metals: Current Status and Trends
10.1021/acscentsci.8b00073 2018-03-26 Group 4 metal-based metal–organic frameworks (MIV-MOFs), including Ti-, Zr-, and Hf-based MOFs, are one of the most attractive classes of MOF materials owing to their superior chemical stability and structural tunability. Despite being a relatively new field,... |
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Looking at the Disordered Proteins through the Computational Microscope
10.1021/acscentsci.7b00626 2018-03-22 Intrinsically disordered proteins (IDPs) have attracted wide interest over the past decade due to their surprising prevalence in the proteome and versatile roles in cell physiology and pathology. A large selection of IDPs has been identified as potential targ... |