XR-11576 HCl Biological
Activity
| Description |
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.
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| In Vitro |
XR-11576 has an inhibitory effect (IC50=0.0121 µ M) on multidrug-resistant human non-small cell lung cancer cell line COR-L23 (COR-L23/R) overexpressing multidrug-resistant protein (MRP).[1]
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| References |
1. Vicker N, et al. Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents. J Med Chem. 2002;45(3):721-739.
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