(2S)-2-Amino(3,3-2H2)butanoic acid

Modify Date: 2024-05-02 22:32:47

(2S)-2-Amino(3,3-2H2)butanoic acid structure	Common Name	(2S)-2-Amino(3,3-2H2)butanoic acid
	CAS Number	352431-37-9	Molecular Weight	105.13
	Density	1.1±0.1 g/cm3	Boiling Point	215.2±23.0 °C at 760 mmHg
	Molecular Formula	C₄H₇D₂NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	83.9±22.6 °C

Use of (2S)-2-Amino(3,3-2H2)butanoic acid

H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

Name	l-2-aminobutyric-3,3-d2 acid
Synonym	More Synonyms

Description	H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Yudkoff M, et al. On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio. Am J Clin Nutr. 1979 Feb;32(2):282-5.

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Yudkoff M, et al. On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio. Am J Clin Nutr. 1979 Feb;32(2):282-5.

Density	1.1±0.1 g/cm3
Boiling Point	215.2±23.0 °C at 760 mmHg
Molecular Formula	C₄H₇D₂NO₂
Molecular Weight	105.13
Flash Point	83.9±22.6 °C
Exact Mass	105.075882
PSA	63.32000
LogP	-0.15
Vapour Pressure	0.1±0.9 mmHg at 25°C
Index of Refraction	1.462

(2S)-2-Amino(3,3-H)butanoic acid

Butanoic-3,3-d acid, 2-amino-, (2S)-

(2S)-2-Amino(3,3-2H2)butanoic acid

Use of (2S)-2-Amino(3,3-2H2)butanoic acid

Names

(2S)-2-Amino(3,3-2H2)butanoic acid Biological Activity

Chemical & Physical Properties

Synonyms