Dihydrouracil-13C4,15N2

Modify Date: 2024-01-05 18:11:59

Dihydrouracil-13C4,15N2 structure	Common Name	Dihydrouracil-13C4,15N2
	CAS Number	360769-22-8	Molecular Weight	120.06
	Density	N/A	Boiling Point	N/A
	Molecular Formula	₁₃C₄H₆₁₅N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dihydrouracil-13C4,15N2

Dihydrouracil-13C4,15N2 is the 13C and 15N labeled Dihydrouracil[1]. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].

Name	Dihydrouracil-13C4,15N2

Description	Dihydrouracil-13C4,15N2 is the 13C and 15N labeled Dihydrouracil[1]. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84(12):2761-2769. [3]. Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74(6):737-744.

Molecular Formula	₁₃C₄H₆₁₅N₂O₂
Molecular Weight	120.06

Dihydrouracil-13C4,15N2

Use of Dihydrouracil-13C4,15N2

Names

Dihydrouracil-13C4,15N2 Biological Activity

Chemical & Physical Properties