Anti-inflammatory agent 11
Modify Date: 2024-03-03 16:11:45
Anti-inflammatory agent 11 structure
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Common Name | Anti-inflammatory agent 11 | ||
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| CAS Number | 63932-07-0 | Molecular Weight | 286.35 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H14N4OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Anti-inflammatory agent 11Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1]. |
| Name | N4-benzyl-iso-nicotinic acid thio-semicarbazide |
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| Synonym | More Synonyms |
| Description | Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1]. |
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| Related Catalog | |
| Target |
TNF-α |
| In Vitro | Anti-inflammatory agent 11 (compound 16) is active in the reduction of accumulated nitrite, with an IC50 of 64.8 ± 1.0 μM[1]. |
| References |
| Molecular Formula | C14H14N4OS |
|---|---|
| Molecular Weight | 286.35 |
| Exact Mass | 286.08900 |
| PSA | 98.14000 |
| LogP | 2.56340 |
| 4-benzyl-1-(4-pyridylcarbonyl)thiosemicarbazide |
| 4-benzyl-1-isonicotinoyl-thiosemicarbazide |
| 4-benzyl-1-(4-pyridoyl) thiosemicarbazide |