Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling

E. Litwa, J. Rzemieniec, A. Wnuk, W. Lason, W. Krzeptowski, M. Kajta

Index: J. Steroid Biochem. Mol. Biol. 144 Pt B , 334-47, (2014)

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Abstract

• Age-dependent action of nonylphenol (NP) on mouse neuronal cells was demonstrated. • Estrogen receptor (ER) antagonists potentiated the NP-induced apoptosis and toxicity. • ER agonists inhibited the NP-evoked effects in mouse hippocampal cells. • The retinoid X receptor (RXR) antagonist inhibited the NP-induced apoptosis. • NP reduced ERα- and ERβ-staining but stimulated RXR-specific immunofluorescence.