Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro.
Daphne Yiu San Wong, Ian Francis Musgrave, Benjamin Scott Harvey, Scott Darryl Smid
Index: Neurosci. Lett. 556 , 221-6, (2013)
Full Text: HTML
Abstract
The native South American palm açaí berry (Euterpe oleraceae Mart.) has high polyphenolic and antioxidant levels. This study examined whether açaí berry extract afforded protection against β-amyloid (Aβ)-mediated loss of cell viability and oxidative stress associated with anti-fibrillar effects. PC12 cells were exposed to either Aβ1-42, Aβ25-35 or tert butyl hydroperoxide (t-BHP), alone or in the presence of açaí extract (0.5-50μg/ml). Thioflavin T (ThT) binding assay and transmission electron microscopy were used to determine effects of açaí extract on Aβ1-42 fibril morphology and compared to açaí phenolics gallic acid, cyanidin rutinoside and cyanidin glucoside. Exposure to Aβ1-42, Aβ25-35 or t-BHP decreased PC12 cell viability. Pretreatment with açaí extract significantly improved cell viability following Aβ1-42 exposure, however Aβ25-35 or t-BHP-mediated viability loss was unaltered. Açaí extract inhibited ThT fluorescence and disrupted Aβ1-42 fibril and aggregate morphology. In comparison with other phenolics, açaí was most effective at inhibiting Aβ1-42 aggregation. Inhibition of β-amyloid aggregation may underlie a neuroprotective effect of açaí. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Related Compounds
Related Articles:
2015-03-01
[J. Cell. Mol. Med. 19(3) , 595-607, (2015)]
2015-01-07
[Org. Biomol. Chem. 13(1) , 269-76, (2014)]
Biocompatibility evaluation of porous ceria foams for orthopedic tissue engineering.
2015-01-01
[J. Biomed. Mater. Res. A 103(1) , 8-15, (2014)]
2015-03-14
[Br. J. Nutr. 113(5) , 770-82, (2015)]
2015-06-01
[Rejuvenation Res. 18 , 225-33, (2015)]