Journal of Pharmaceutical Sciences 2014-06-01

Passive and iontophoretic transport of fluorides across enamel in vitro.

Wei Ren, Arif Baig, S Kevin Li

Index: J. Pharm. Sci. 103(6) , 1692-700, (2014)

Full Text: HTML

Abstract

Passive and iontophoretic transport of fluoride from three fluoride sources, NaF, sodium monofluorophosphate (MFP), and SnF2 solutions, across bovine enamel was investigated to (1) determine the characteristics of the intrinsic barrier of enamel for ion transport, (2) examine the feasibility of iontophoretically enhanced transport of fluoride across enamel, and (3) identify the transport mechanisms involved in enamel iontophoresis. Conductivity experiments were performed with bovine enamel specimens in side-by-side diffusion cells to evaluate the electrical and barrier properties of the enamel with electrolytes of different ion sizes and under different ion concentrations and pH conditions in vitro. Transport experiments of the enamel were performed in the diffusion cells with the NaF, MFP, and SnF2 solutions. The conductivity results showed that the enamel specimens behaved as a neutral membrane or that of low pore charge density. Cathodal iontophoresis significantly enhanced the delivery of fluoride ions across the enamel from the solutions over passive transport, consistent with Nernst-Planck theory and the direct field effect (i.e., electrophoresis) as the dominant flux-enhancing mechanism. The enamel demonstrated significant transport hindrance for the ions, and the effective pore radii of the transport pathways in the enamel were found to be approximately 0.7-0.9 nm.© 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.


Related Compounds

Related Articles:

Functional consequence of the MET-T1010I polymorphism in breast cancer.

2015-02-20

[Oncotarget 6(5) , 2604-14, (2015)]

Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.

2014-01-01

[PLoS ONE 9(12) , e116152, (2014)]

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.

2015-05-01

[Biomaterials 51 , 1-11, (2015)]

Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells.

2015-04-01

[J. Pineal Res. 58(3) , 310-20, (2015)]

25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.

2015-04-22

[J. Ethnopharmacol. 164 , 265-72, (2015)]

More Articles...