Antimicrobial Agents and Chemotherapy 2010-01-01

Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli.

Nazia Kamal, William M Shafer

Index: Antimicrob. Agents Chemother. 54 , 506-8, (2010)

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Abstract

Neisseria meningitidis can produce a TolC-like protein needed for secretion of FrpC but not efflux of antimicrobials. We now report that expression of the meningococcal tolC gene in a TolC-deficient strain of Escherichia coli can restore properties of alpha-hemolysis and antimicrobial resistance known to involve efflux pumps.

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