Nature Communications 2014-01-01

Interfacial assembly of dendritic microcapsules with host-guest chemistry.

Yu Zheng, Ziyi Yu, Richard M Parker, Yuchao Wu, Chris Abell, Oren A Scherman

Index: Nat. Commun. 5 , 5772, (2014)

Full Text: HTML

Abstract

The self-assembly of nanoscale materials to form hierarchically ordered structures promises new opportunities in drug delivery, as well as magnetic materials and devices. Herein, we report a simple means to promote the self-assembly of two polymers with functional groups at a water-chloroform interface using microfluidic technology. Two polymeric layers can be assembled and disassembled at the droplet interface using the efficiency of cucurbit[8]uril (CB[8]) host-guest supramolecular chemistry. The microcapsules produced are extremely monodisperse in size and can encapsulate target molecules in a robust, well-defined manner. In addition, we exploit a dendritic copolymer architecture to trap a small hydrophilic molecule in the microcapsule skin as cargo. This demonstrates not only the ability to encapsulate small molecules but also the ability to orthogonally store both hydrophilic and hydrophobic cargos within a single microcapsule. The interfacially assembled supramolecular microcapsules can benefit from the diversity of polymeric materials, allowing for fine control over the microcapsule properties.


Related Compounds

Related Articles:

A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.

2015-05-01

[J. Virol. 89(9) , 4918-31, (2015)]

Aqueous-core PEG-coated PLA nanocapsules for an efficient entrapment of water soluble anticancer drugs and a smart therapeutic response.

2015-01-01

[Eur. J. Pharm. Biopharm. 89 , 30-9, (2015)]

SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression.

2015-01-01

[Nucleic Acids Res. 42(18) , 11433-46, (2014)]

The dynamics of giant unilamellar vesicle oxidation probed by morphological transitions.

2014-10-01

[Biochim. Biophys. Acta 1838(10) , 2615-24, (2014)]

The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184.

2014-09-01

[Pharmacol. Biochem. Behav. 124 , 153-9, (2014)]

More Articles...