Blood 2014-10-16

Erythroferrone contributes to recovery from anemia of inflammation.

Léon Kautz, Grace Jung, Elizabeta Nemeth, Tomas Ganz

Index: Blood 124(16) , 2569-74, (2014)

Full Text: HTML

Abstract

Erythroferrone (ERFE) is an erythropoiesis-driven regulator of iron homeostasis. ERFE mediates the suppression of the iron-regulatory hormone hepcidin to increase iron absorption and mobilization of iron from stores. We examined the role of ERFE in the recovery from anemia of inflammation (AI) induced by injection of heat-killed Brucella abortus. B abortus-treated wild-type mice developed a moderate anemia and reached nadir hemoglobin 14 days after injection and partially recovered by 28 days. We observed that Erfe expression in the bone marrow and the spleen was greatly increased during anemia and peaked at 14 days after injection, a time course similar to serum erythropoietin. To determine whether ERFE facilitates the recovery from anemia, we analyzed Erfe-deficient mice injected with B abortus. Compared with wild-type mice, Erfe-deficient mice exhibited a more severe anemia, had higher hepcidin levels and consequently lower serum iron concentration on days 14 and 21, and manifested impaired mobilization of iron from stores (liver and spleen). Erfe(-/-) mice eventually compensated by further stimulating erythropoiesis and reticulocyte production. Thus, ERFE contributes to the recovery from AI by suppressing hepcidin and increasing iron availability. © 2014 by The American Society of Hematology.


Related Compounds

Related Articles:

Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.

2014-12-16

[Nucleic Acids Res. 42(22) , 14022-30, (2014)]

The dynamics of giant unilamellar vesicle oxidation probed by morphological transitions.

2014-10-01

[Biochim. Biophys. Acta 1838(10) , 2615-24, (2014)]

Investigations on the transfer of porphyrin from o/w emulsion droplets to liposomes with two different methods.

2015-01-01

[Drug Dev. Ind. Pharm. 41(1) , 156-62, (2014)]

β-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A.

2014-01-01

[PLoS ONE 9(11) , e112818, (2014)]

Coculture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells on strontium-doped calcium polyphosphate scaffolds to generate vascularized engineered bone.

2015-03-01

[Tissue Eng. Part A 21(5-6) , 948-59, (2015)]

More Articles...