Archives of Gynecology and Obstetrics 2013-03-01

Changes in the size of rectovaginal endometriotic nodules infiltrating the rectum during hormonal therapies.

Simone Ferrero, Umberto Leone Roberti Maggiore, Carolina Scala, Martina Di Luca, Pier Luigi Venturini, Valentino Remorgida

Index: Arch. Gynecol. Obstet. 287(3) , 447-53, (2013)

Full Text: HTML

Abstract

To evaluate the changes in the volume of rectovaginal endometriotic nodules infiltrating the rectum during 12-month treatment with hormonal therapies.This prospective, non-randomized, self-controlled clinical trial included patients with rectovaginal endometriotic nodules infiltrating at least the muscularis propria of the rectum, who received one of the following therapies: norethisterone acetate, triptorelin and tibolone, norethisterone acetate and letrozole, desogestrel, sequential oral contraceptive pill. The volume of the nodules was determined by virtual organ computer-aided analysis (VOCAL, GE Healthcare, USA) at baseline and after 6 and 12 months of treatment.Eighty-three women (90.2 %) completed the 12-month treatment. When compared with baseline values, the volume of the nodules decreased at 6-month (p < 0.001) and 12-month treatment (p < 0.001). After 12-month treatment, the volume of the nodules decreased in all study groups. The volume of the nodules decreased during therapy in 68 women (73.9 %) and increased in 11 women (12.0 %).12-month administration of hormonal therapies reduces the volume of rectovaginal endometriotic nodules infiltrating the rectum in the majority of cases.


Related Compounds

Related Articles:

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

2010-01-01

[Chem. Res. Toxicol. 23 , 171-83, (2010)]

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

2011-12-01

[J. Sci. Ind. Res. 65(10) , 808, (2006)]

Developing structure-activity relationships for the prediction of hepatotoxicity.

2010-07-19

[Chem. Res. Toxicol. 23 , 1215-22, (2010)]

A predictive ligand-based Bayesian model for human drug-induced liver injury.

2010-12-01

[Drug Metab. Dispos. 38 , 2302-8, (2010)]

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

2014-12-29

[J. Chromatogr. A. 1374 , 122-33, (2014)]

More Articles...