Design of a photoswitchable hollow microcapsular drug delivery system by using a supramolecular drug-loading approach.
Wang Xiao, Wei-Hai Chen, Jing Zhang, Cao Li, Ren-Xi Zhuo, Xian-Zheng Zhang
Index: J. Phys. Chem. B 115 , 13796-13802, (2011)
Full Text: HTML
Abstract
In this study, photoswitchable microcapsules were fabricated based on host-guest interactions between α-cyclodextrin (α-CD) and azobenzene (Azo). Carboxymethyl dextran-graft-α-CD (CMD-g-α-CD) and poly(acrylic acid) N-aminododecane p-azobenzeneaminosuccinic acid (PAA-C(12)-Azo) were assembled layer by layer on CaCO(3) particles. α-CD-rhodamine B (α-CD-RhB), used as a model drug, was loaded on PAA-C(12)-Azo layers by host-guest interaction. After removal of CaCO(3) particles by ethylenediaminetetraacetic acid (EDTA), hollow microcapsules loaded with α-CD-RhB were obtained. Since the interactions between α-CD and Azo were photosensitive, the capsules could be dissociated with the irradiation of UV light, followed by the release of the model drug, α-CD-RhB. Compared with traditional drug-loading approaches such as chemical bonding and physical adsorption, our supramolecular drug-loading system has a facile loading process, ideal bonding strength, and photoswitchable behavior. These photosensitive microcapsules exhibit great potential in biomedical applications.© 2011 American Chemical Society
Related Compounds
Related Articles:
2012-02-01
[Acta Biomater. 8 , 619-626, (2012)]
Characterization of Chitosan-Carboxymethyl Dextran Nanoparticles as a Drug Carrier and as a Stimulator of Mouse Splenocytes. Lin YS, Radzi R, Morimoto M, et al.
[J. Biomater. Sci. Polym. Ed. , doi: 10.1163/092050611X582849, (2011)]
in vitromorphogenesis of PANC-1 cells into islet-like aggregates using RGD-covered dextran derivative surfaces. Dubiel EA, Kuehn C, Wang R, Vermette P.
[Colloids Surf., B 89 , 117-125, (2012)]