Journal of Pharmaceutical and Biomedical Analysis 2015-01-01

Quantification of nerolidol in mouse plasma using gas chromatography-mass spectrometry.

Alexandre Yukio Saito, Rodrigo Antonio Ceschini Sussmann, Emilia Akemi Kimura, Maria Belen Cassera, Alejandro Miguel Katzin

Index: J. Pharm. Biomed. Anal. 111 , 100-3, (2015)

Full Text: HTML

Abstract

Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of flowers and plants. It is frequently used in cosmetics, as a food flavoring agent, and in cleaning products. In addition, nerolidol is used as a skin penetration enhancer for transdermal delivery of therapeutic drugs. However, nerolidol is hemolytic at low concentrations. A simple and fast GC-MS method was developed for preliminary quantification and assessment of biological interferences of nerolidol in mouse plasma after oral dosing. Calibration curves were linear in the concentration range of 0.010-5 μg/mL nerolidol in mouse plasma with correlation coefficients (r) greater than 0.99. Limits of detection and quantification were 0.0017 and 0.0035 μg/mL, respectively. The optimized method was successfully applied to the quantification of nerolidol in mouse plasma.Copyright © 2015 Elsevier B.V. All rights reserved.


Related Compounds

Related Articles:

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

2014-09-26

[J. Chromatogr. A. 1361 , 265-76, (2014)]

The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184.

2014-09-01

[Pharmacol. Biochem. Behav. 124 , 153-9, (2014)]

Effect of germinated brown rice extracts on pancreatic lipase, adipogenesis and lipolysis in 3T3-L1 adipocytes.

2014-01-01

[Lipids Health Dis. 13 , 169, (2014)]

Influence of surface modification on wettability and surface energy characteristics of pharmaceutical excipient powders.

2014-11-20

[Int. J. Pharm. 475(1-2) , 351-63, (2014)]

Quantitative analysis of glycerol levels in human urine by liquid chromatography–tandem mass spectrometry

2014-04-15

[J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 30-5, (2014)]

More Articles...