Thermoresponsive dendrimers based on oligoethylene glycols: design, synthesis and cytotoxic activity against MCF-7 breast cancer cells.

Mona A Abdel-Rahman, Ahmed M Al-Abd

Index: Eur. J. Med. Chem. 69 , 848-54, (2013)

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Abstract

Three interesting thermoresponsive branched oligoethylene glycol dendrimers based on tetrabromohydroquinone were efficiently synthesized from tetrabromohydroquinone and three different oligoethylene glycol derivatives. By visual inspection, all these dendrimers are water-soluble at room temperature. The thermoresponsive behaviors were investigated by using UV/vis turbidity measurement at different temperatures for 0.25 wt% of aqueous solutions from D1, D2 and D3. The cytotoxicity of the prepared dendrimers was tested against MCF-7 breast cancer cells. All tested dendrimers showed considerable results, where D2 dendrimer gave the best result; it showed cytotoxicity against MCF-7 cell line with IC₅₀ of 1.07 μg/mL and resistant fraction equals 1.97%, the other two dendrimers showed a modest cytotoxic profile.Copyright © 2013 Elsevier Masson SAS. All rights reserved.